Enantioselective and Diastereoselective Conjugate Radical Additions to -Arylidene Ketones and Lactones

被引：3

作者：

Zhao, Changjia ^{[1
]}

Sibi, Mukund P. ^{[1
]}

机构：

[1] North Dakota State Univ, Dept Chem & Biochem, POB 2735, Fargo, ND 58108 USA

来源：

SYNLETT | 2017年 / 28卷 / 20期

关键词：

enantioselective radical reaction; arylidene ketones and lactones; diastereoselectivity; conjugate addition; chiral salen Lewis acid; LEWIS-ACID CATALYSIS; ALPHA-AMINO RADICALS; PHOTOREDOX CATALYSIS; BRONSTED ACID; LIGANDS; ENONES;

D O I：

10.1055/s-0036-1590930

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly stereoselective conjugate radical addition to arylidene ketones and lactones has been developed. The conjugate radical additions using chiral salen Lewis acids proceeds with up to 99:1 dr and 87% ee in good to excellent chemical yields.

引用

页码：2971 / 2975

页数：5

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