CD8+ T cell metabolism in infection and cancer

Cytotoxic CD8(+) T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8(+) T cell metabolism is coupled to transcriptional, translational and epigenetic changes that are driven by extracellular metabolites and immunological signals. These programmes facilitate the adaptation of CD8(+) T cells to the diverse and dynamic metabolic environments encountered in the circulation and in the tissues. In the setting of disease, both cell-intrinsic and cell-extrinsic metabolic cues contribute to CD8(+) T cell dysfunction. In addition, changes in whole-body metabolism, whether through voluntary or disease-induced dietary alterations, can influence CD8(+) T cell-mediated immunity. Defining the metabolic adaptations of CD8(+) T cells in specific tissue environments informs our understanding of how these cells protect against pathogens and tumours and maintain tissue health at barrier sites. Here, we highlight recent findings revealing how metabolic networks enforce specific CD8(+) T cell programmes and discuss how metabolism is integrated with CD8(+) T cell differentiation and function and determined by environmental cues. This Review examines the metabolic adaptations that occur in CD8(+) T cells in the settings of infection and cancer. The authors discuss the key metabolic features of activated, memory, tissue-resident and dysfunctional CD8(+) T cell populations and also consider how overall host metabolism can affect the CD8(+) T cell response.