Role of Vitamin C in Prevention of Preeclampsia in High-Risk Cases: Randomized Controlled Trial

被引：0
|
作者：
Torky, Haitham A. [1 ,2 ]
Abo-Louz, Ashraf [1 ,2 ]
Deif, Osama [2 ,3 ]
Moussa, Asem [2 ,3 ]
Aly, Rania [2 ,4 ]
Shata, Atef [2 ,5 ]
Ragab, Mona [6 ]
El-Taher, Osama S. [6 ]
Hussein, Ahmed [1 ,2 ]
机构：
[1] October 6th Univ, Dept Obstet & Gynecol, Cairo, Egypt
[2] Air Force Specialized Hosp, Cairo, Egypt
[3] Al Azhar Univ, Dept Obstet & Gynecol, Cairo, Egypt
[4] Al Galaa Teaching Hosp, Dept Obstet & Gynecol, Cairo, Egypt
[5] Matariya Teaching Hosp, Dept Obstet & Gynecol, Cairo, Egypt
[6] Al Galaa Teaching Hosp, Air Force Specialized Hosp, Dept Obstet & Gynecol, Cairo, Egypt
来源：
INTERNATIONAL JOURNAL OF CHILDBIRTH | 2021年 / 11卷 / 01期
关键词：
preeclampsia; prevention; high-risk; vitamin C; OXIDATIVE STRESS; ANTIOXIDANTS; PREGNANCY;
D O I：
10.1891/IJCBIRTH-D-20-00027
中图分类号：
R47 [护理学];
学科分类号：
1011 ;
摘要：
OBJECTIVE: To evaluate the effect of vitamin C intake on the incidence of preeclampsia in high-risk cases. METHODOLOGY: Prospective double-blinded multi-center randomized controlled trial involving 940 qualified patients equally divided into two groups one receiving vitamin C and the other receiving placebo starting from 12 weeks gestational age. RESULTS: No significant difference was found between vitamin C and placebo on the incidence of preeclampsia, maternal problems (prelabor rupture of membranes, antepartum hemorrhage, and placental abruption), and fetal outcomes (birth weight, Apgar scores, preterm delivery, admission to NICU, and low birth weight). CONCLUSION: Vitamin C intake in pregnancy is not recommended for prevention of preeclampsia, maternal or fetal problems in cases at high-risk for developing preeclampsia.
引用
收藏
页码：20 / 26
页数：7
相关论文
共 50 条
  • [31] Comparative efficacy of pitavastatin and simvastatin in high-risk patients: a randomized controlled trial
    Mats Eriksson
    Dragos Budinski
    Neil Hounslow
    [J]. Advances in Therapy, 2011, 28 : 811 - 823
  • [32] EARLY PHYSICAL THERAPY EFFECTS ON THE HIGH-RISK INFANT - A RANDOMIZED CONTROLLED TRIAL
    PIPER, MC
    KUNOS, VI
    WILLIS, DM
    MAZER, BL
    RAMSAY, M
    SILVER, KM
    [J]. PEDIATRICS, 1986, 78 (02) : 216 - 224
  • [33] Randomized Controlled Trial of a Spring Break Intervention to Reduce High-Risk Drinking
    Lee, Christine M.
    Neighbors, Clayton
    Lewis, Melissa A.
    Kaysen, Debra
    Mittmann, Angela
    Geisner, Irene M.
    Atkins, David C.
    Zheng, Cheng
    Garberson, Lisa A.
    Kilmer, Jason R.
    Larimer, Mary E.
    [J]. JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 2014, 82 (02) : 189 - 201
  • [34] Reducing Tobacco Smoke Exposure in High-Risk Infants: A Randomized, Controlled Trial
    Stotts, Angela L.
    Northrup, Thomas F.
    Green, Charles
    Suchting, Robert
    Hovell, Melbourne F.
    Khan, Amir
    Villarreal, Yolanda R.
    Schmitz, Joy M.
    Velasquez, Mary M.
    Hammond, S. Katharine
    Hoh, Eunha
    Tyson, Jon
    [J]. JOURNAL OF PEDIATRICS, 2020, 218 : 35 - +
  • [35] Ranibizumab for High-Risk Proliferative Diabetic Retinopathy: An Exploratory Randomized Controlled Trial
    Figueira, Joao
    Silva, Rufino
    Henriques, Jose
    Rosa, Paulo Caldeira
    Lains, Ines
    Melo, Pedro
    Nunes, Sandrina Goncalves
    Cunha-Vaz, Jose
    [J]. OPHTHALMOLOGICA, 2016, 235 (01) : 34 - 41
  • [36] Prophylactic penehyclidine inhalation for prevention of postoperative pulmonary complications in high-risk patients: study protocol of a randomized controlled trial
    Ting Yan
    Xin-Quan Liang
    Tong Wang
    Wei-Ou Li
    Hui-Juan Li
    Sai-Nan Zhu
    Dong-Xin Wang
    [J]. Trials, 18
  • [37] Simvastatin and Vitamin D for Migraine Prevention: A Randomized, Controlled Trial
    Buettner, Catherine
    Nir, Rony-Reuven
    Bertisch, Suzanne M.
    Bernstein, Carolyn
    Schain, Aaron
    Mittleman, Murray A.
    Burstein, Rami
    [J]. ANNALS OF NEUROLOGY, 2015, 78 (06) : 970 - 981
  • [38] Prophylactic penehyclidine inhalation for prevention of postoperative pulmonary complications in high-risk patients: study protocol of a randomized controlled trial
    Yan, Ting
    Liang, Xin-Quan
    Wang, Tong
    Li, Wei-Ou
    Li, Hui-Juan
    Zhu, Sai-Nan
    Wang, Dong-Xin
    [J]. TRIALS, 2017, 18
  • [39] Torsemide for Prevention of Persistent Postpartum Hypertension in Women With Preeclampsia A Randomized Controlled Trial
    Viteri, Oscar A.
    Alrais, Mesk A.
    Pedroza, Claudia
    Hutchinson, Maria
    Chauhan, Suneet P.
    Blackwell, Sean C.
    Sibai, Baha M.
    [J]. OBSTETRICS AND GYNECOLOGY, 2018, 132 (05): : 1185 - 1191
  • [40] A RANDOMIZED TRIAL COMPARING TICLOPIDINE HYDROCHLORIDE WITH ASPIRIN FOR THE PREVENTION OF STROKE IN HIGH-RISK PATIENTS
    HASS, WK
    EASTON, JD
    ADAMS, HP
    PRYSEPHILLIPS, W
    MOLONY, BA
    ANDERSON, S
    KAMM, B
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (08): : 501 - 507
12345