In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides

被引:0
|
作者
Devienne, KF
Raddi, MSG [1 ]
Varanda, EA
Vilegas, W
机构
[1] Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
[2] Univ Estadual Paulista, Inst Quim Araraquara, BR-14801902 Araraquara, SP, Brazil
来源
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2002年 / 57卷 / 1-2期
关键词
Paepalanthus bromelioides; isocoumarin; cytotoxicity activity;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromehoides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.
引用
收藏
页码:85 / 88
页数:4
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