In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides

被引：0

作者：

Devienne, KF

Raddi, MSG ^{[1
]}

Varanda, EA

Vilegas, W

机构：

[1] Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil

[2] Univ Estadual Paulista, Inst Quim Araraquara, BR-14801902 Araraquara, SP, Brazil

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2002年 / 57卷 / 1-2期

关键词：

Paepalanthus bromelioides; isocoumarin; cytotoxicity activity;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of isocoumarins similar to 9,10-dihydroxy-5,7-dimethoxy-1H-naphtho(2,3c)pyran-1-one (paepalantine 1). Paepalantine 1 has antimicrobial activity, as well as significant in vitro cytotoxic effects in the McCoy cell line. Two other natural and two semi-synthetic isocoumarins with similar structures obtained from the capitula of Paepalanthus bromehoides were tested on the same cell line by the neutral red assay. Substitution of the 9 and/or 10-OH group made these compounds less cytotoxic.

引用

页码：85 / 88

页数：4

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