Pharmacokinetics of Coenzyme Q10

被引：8
|
作者：
Kalenikova, E. I. [1 ]
Gorodetskaya, E. A. [1 ]
Medvedev, O. S. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Fac Basic Med, Dept Pharmacol, Moscow 117234, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 146卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
coenzyme Q(10); solubilized form; pharmacokinetics; bioavailability;
D O I：
10.1007/s10517-008-0270-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The pharmacokinetics of coenzyme Q(10) powder and solution of solubilized form was studied after their oral administration to rats (10 mg/kg). Plasma concentrations of coenzyme Q(10) were measured by HPLC with electrochemical detection over 48 hours. Solubilized coenzyme Q(10) exhibited high absorption creating higher plasma concentrations of the drug, as a result of which its bioavailability constituted 264% of that for the powder.
引用
收藏
页码：313 / 316
页数：4
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