Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells

被引：0
|
作者：
Komiya, T
Kyohkon, M
Ohwaki, S
Eto, J
Katsuzaki, H
Imai, K
Kataoka, T
Yoshioka, K
Ishii, Y
Hibasami, H [1 ]
机构：
[1] Mie Univ, Fac Med, Tsu, Mie 5140001, Japan
[2] Mie Univ, Fac Bioresources, Tsu, Mie 5140001, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 1999年 / 4卷 / 04期
关键词：
phytol; growth inhibition; apoptosis; DNA fragmentation; human lymphoid leukemia;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The exposure of human lymphoid leukemia Molt 4B cells to phytol which was isolated from Lolium multiflorum Lam and identified by MS, and H-1- and C-13-NMR, led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological change showing apoptotic bodies was observed in the cells treated with phytol. The fragmentation by phytol of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition by phytol of Molt 4B cells results from the induction of apoptosis in the cells.
引用
收藏
页码：377 / 380
页数：4
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