SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON NITROGEN AND OXYGEN-BASED BI DENTATE MANNICH BASE LIGAND OF TRANSITION METAL COMPLEXES

1-{3-[2, 3dihydro-1H-imidazol-1-yl (8-hydroxyquinolin-7-yl) methyl] phenyl-l} ethanon, nitrogen and oxygen-based bi-dentate mannich base heterocyclic ligand synthesized and complexed with biologically significant transition metals like copper, cobalt, nickel, and zinc by the melt condensation three-component one-pot synthesis. All the synthesized potential compounds characterized by spectral methods by using NMR, IR, UV-visible mass, and elemental analysis. The antimicrobial analysis investigated for all the synthesized compounds using some bacterial and fungal cultures used by the disc diffusion method, and the activity proved in proportion with the standard drugs used as a reference. The main significant part of the work involved in mannich base reaction of one-pot synthesis three-component reactions prove better synthetic procedure and improved product yield. The ligand and the complexes of transition metals proved better microbial activities of biologically important and to prove the efficiency of the present work. Continuation of research work is to investigate significant heterocyclic molecules and transition metal complexes to prove potential microbial activities play an important role in pharmaceutical and biological applications.