Convenient synthesis of novel pyrimido[4,5-b][1,5]benzothiazepines

被引：2
|
作者：
Nikpour, Mohsen [1 ]
Hasanzadeh, Neda [1 ]
机构：
[1] Islamic Azad Univ, Ahvaz Branch, Dept Chem, Ahwaz 6134968875, Iran
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 12期
关键词：
SOLVENT-FREE SYNTHESIS; BIOLOGICAL EVALUATION; 1,5-BENZOTHIAZEPINE DERIVATIVES; 15-LIPOXYGENASE INHIBITORS; POTENT ANTIFUNGAL; IN-VITRO; ANTIBACTERIAL; DESIGN;
D O I：
10.1002/jhet.4141
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of 4,6-dichloropyrimidine-5-carbaldehyde with amines in chloroform gave 4-(substitutedamino)-6-chloro-pyrimidine-5-carbaldehydes derivatives at low temperature. Treatment of the latter products with 2-aminobenzenethiol in alkaline benzene and then in boiling acetonitrile gave a novel group of 11H-pyrimido[4,5-b][1,5]benzodiazepine derivatives. Structures of the products confirmed by(1)HNMR, IR, and mass spectra.
引用
收藏
页码：4380 / 4384
页数：5
相关论文
共 50 条
  • [21] Synthesis of Some Pyrimido[4,5-b]quinoline Derivatives
    Marjani, Ahmad Poursattar
    Khalafy, Jabbar
    Ebrahimlo, Ali Reza Molla
    Prager, Rolf H.
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2011, 32 (07) : 2183 - 2186
  • [22] Enantioconservative Synthesis of Polysubstituted Pyrimido[4,5-b]azepines
    Gerig, Britta
    Girreser, Ulrich
    Schuett, Martin
    Heber, Dieter
    SYNTHESIS-STUTTGART, 2010, (12): : 2017 - 2022
  • [23] Fast and efficient regioselective synthesis of a novel eight membered ring system, 5H-benzo[f]pyrimido[4,5-b][1,5]oxazocine
    Toktam Afrough
    Hossein Eshghi
    Monatshefte für Chemie - Chemical Monthly, 2021, 152 : 475 - 479
  • [24] CONVENIENT SYNTHESES OF PYRIMIDINO[4,5-B] [1,5]BENZODIAZEPINONES AND PYRIMIDINO[1,6-A] BENZIMIDAZOLONES
    AOTSUKA, T
    MORITA, H
    TAKAGI, K
    OKAMOTO, Y
    SYNTHESIS-STUTTGART, 1986, (08): : 668 - 670
  • [25] SYNTHESIS OF SOME PYRIMIDO[4,5-B][1,4]OXAZINES FROM 5-AMINOPYRIMIDINES
    MELIKAGANDZHANYAN, RG
    KHACHATURYAN, TA
    MIRZOYAN, VS
    MANUKYAN, AG
    STEPANYAN, GM
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1985, (07): : 974 - 976
  • [26] Fast and efficient regioselective synthesis of a novel eight membered ring system, 5H-benzo[f]pyrimido[4,5-b][1,5]oxazocine
    Afrough, Toktam
    Eshghi, Hossein
    MONATSHEFTE FUR CHEMIE, 2021, 152 (04): : 475 - 479
  • [27] SYNTHESIS OF QUNOLINO[4,5-B,C][1,5]-BENZODIAZEPINE-DERIVATIVES
    EIDEN, F
    RAUTENFELD, RBV
    ARCHIV DER PHARMAZIE, 1976, 309 (04) : 309 - 316
  • [28] SYNTHESIS OF SUBSTITUTED DIHYDROBENZO[H]PYRIMIDO[4,5-B]QUINOLINES AND SUBSTITUTED DIHYDROBENZO[F]PYRIMIDO[4,5-B]QUINOLINES AS TETRACYCLIC 5-DEAZA NONCLASSICAL FOLATES
    DONKOR, IO
    GANGJEE, A
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 200 : 143 - MEDI
  • [29] Pharmacological characterization of the novel pyrimido[4,5-b]indole (APPPI)
    Brand, A
    Eschke, D
    Hess, S
    Müller, C
    Eger, K
    Nieber, K
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2001, 363 (04) : R95 - R95
  • [30] Improved synthesis of functionalized 5,6-dihydro-pyrimido[4,5-b][1,4]oxazepines
    Xu, YJ
    Liu, H
    Pan, WT
    Chen, X
    Wong, WC
    Labelle, M
    TETRAHEDRON LETTERS, 2005, 46 (44) : 7523 - 7526
12345