Convenient synthesis of novel pyrimido[4,5-b][1,5]benzothiazepines

被引：2
|
作者：
Nikpour, Mohsen [1 ]
Hasanzadeh, Neda [1 ]
机构：
[1] Islamic Azad Univ, Ahvaz Branch, Dept Chem, Ahwaz 6134968875, Iran
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 12期
关键词：
SOLVENT-FREE SYNTHESIS; BIOLOGICAL EVALUATION; 1,5-BENZOTHIAZEPINE DERIVATIVES; 15-LIPOXYGENASE INHIBITORS; POTENT ANTIFUNGAL; IN-VITRO; ANTIBACTERIAL; DESIGN;
D O I：
10.1002/jhet.4141
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of 4,6-dichloropyrimidine-5-carbaldehyde with amines in chloroform gave 4-(substitutedamino)-6-chloro-pyrimidine-5-carbaldehydes derivatives at low temperature. Treatment of the latter products with 2-aminobenzenethiol in alkaline benzene and then in boiling acetonitrile gave a novel group of 11H-pyrimido[4,5-b][1,5]benzodiazepine derivatives. Structures of the products confirmed by(1)HNMR, IR, and mass spectra.
引用
收藏
页码：4380 / 4384
页数：5
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