One-step synthesis of radioiodinated biotin derivatives

被引：8
|
作者：
Foulon, CF [1 ]
Adelstein, SJ [1 ]
Kassis, AI [1 ]
机构：
[1] HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 07期
关键词：
D O I：
10.1016/0960-894X(96)00106-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A direct method of radioiodination of biotin derivatives is presented whereby radiolabeled sodium iodide is exchanged with a tributylstannyl group under oxidative conditions. The in vitro binding of each radioiodinated biotin derivative to streptavidin is saturable acid three of the compounds exhibit a strong affinity for streptavidin. All the biotin-streptavidin complexes are rapidly catabolized in human serum. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：779 / 784
页数：6
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