Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections

被引：36

作者：

MacLeod, Angus M. ^{[1
]}

Mitchell, Dale R. ^{[1
]}

Palmer, Nicholas J. ^{[1
]}

de Poel, Herve Van ^{[1
]}

Conrath, Katja ^{[3
]}

Andrews, Martin ^{[3
]}

Leyssen, Pieter ^{[2
]}

Neyts, Johan ^{[2
]}

机构：

[1] BioFocus, Dept Med Chem, Cambridge CBIO 1XL, England

[2] Univ Leuven, Rega Inst Med Res, Lab Virol & Chemotherapy, Louvain, Belgium

[3] Galapagos NV, Generaal Wittelaan, B-2800 Mechelen, Belgium

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2013年 / 4卷 / 07期

关键词：

antiviral; enterovirus; HCV; inhibitor; PI4KIII beta; C VIRUS-REPLICATION; RHINOVIRUS COLDS; DOUBLE-BLIND; EXACERBATIONS; PLECONARIL; INHIBITORS; EFFICACY; SAFETY; ALPHA; BETA;

D O I：

10.1021/ml400095m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIII beta. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.

引用

页码：20 / 24

页数：5

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