Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections

被引：36

作者：

MacLeod, Angus M. ^{[1
]}

Mitchell, Dale R. ^{[1
]}

Palmer, Nicholas J. ^{[1
]}

de Poel, Herve Van ^{[1
]}

Conrath, Katja ^{[3
]}

Andrews, Martin ^{[3
]}

Leyssen, Pieter ^{[2
]}

Neyts, Johan ^{[2
]}

机构：

[1] BioFocus, Dept Med Chem, Cambridge CBIO 1XL, England

[2] Univ Leuven, Rega Inst Med Res, Lab Virol & Chemotherapy, Louvain, Belgium

[3] Galapagos NV, Generaal Wittelaan, B-2800 Mechelen, Belgium

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2013年 / 4卷 / 07期

关键词：

antiviral; enterovirus; HCV; inhibitor; PI4KIII beta; C VIRUS-REPLICATION; RHINOVIRUS COLDS; DOUBLE-BLIND; EXACERBATIONS; PLECONARIL; INHIBITORS; EFFICACY; SAFETY; ALPHA; BETA;

D O I：

10.1021/ml400095m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIII beta. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.

引用

页码：20 / 24

页数：5

共 50 条

[1] Antiviral drug discovery for the treatment of enterovirus 71 infections
Shang, Luqing
Xu, Mengying
Yin, Zheng
ANTIVIRAL RESEARCH, 2013, 97 (02) : 183 - 194
[2] Magnesium lithospermate B and rosmarinic acid, two compounds present in Salvia miltiorrhiza, have potent antiviral activity against enterovirus 71 infections
Chung, Yi-Ching
Hsieh, Feng-Chia
Lin, Ying-Ju
Wu, Tzong-Yuan
Lin, Cheng-Wen
Lin, Ching-Ting
Tang, Nou-Ying
Jinn, Tzyy-Rong
EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, 755 : 127 - 133
[3] 2-phenylimidazopyridines, a new series of Golgi compounds with potent antiviral activity
Banie, Homayon
Sinha, Anjana
Thomas, Richard J.
Sircar, Jagadish C.
Richards, Mark L.
JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (24) : 5984 - 5993
[4] Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo
Li, Yuexiang
Liu, Miaomiao
Yan, Yunzheng
Wang, Zhuang
Dai, Qingsong
Yang, Xiaotong
Guo, Xiaojia
Li, Wei
Chen, Xingjuan
Cao, Ruiyuan
Zhong, Wu
VIRUSES-BASEL, 2022, 14 (06):
[5] In vitro evaluation of the antiviral activity of heparan sulfate mimetic compounds against Enterovirus 71
Pourianfar, Hamid Reza
Poh, Chit Laa
Fecondo, John
Grollo, Lara
VIRUS RESEARCH, 2012, 169 (01) : 22 - 29
[6] Treatment of human enterovirus infections
Rotbart, HA
O'Connell, JF
McKinlay, MA
ANTIVIRAL RESEARCH, 1998, 38 (01) : 1 - 14
[7] Enterovirus infections: diagnosis and treatment
Sawyer, MH
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1999, 18 (12) : 1033 - 1040
[8] Treatment of Neonatal Enterovirus Infections
Modlin, John F.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2016, 5 (01) : 63 - +
[9] Enterovirus infections: diagnosis and treatment
Sawyer, MH
CURRENT OPINION IN PEDIATRICS, 2001, 13 (01) : 65 - 69
[10] A Novel Capsid Binding Inhibitor Displays Potent Antiviral Activity against Enterovirus D68
Ma, Chunlong
Hu, Yanmei
Zhang, Jiantao
Musharrafieh, Rami
Wang, Jun
ACS INFECTIOUS DISEASES, 2019, 5 (11): : 1952 - 1962

← 1 2 3 4 5 →