Hippocampal Neurogenesis in Alzheimer's Disease: Is There a Role for Dietary Modulation?

被引：47

作者：

Maruszak, Aleksandra ^{[1
]}

Pilarski, Adam ^{[1
]}

Murphy, Tytus ^{[1
]}

Branch, Nicholas ^{[1
]}

Thuret, Sandrine ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, Dept Neurosci, London SE5 9NU, England

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 38卷 / 01期

关键词：

Alzheimer's disease; calorie restriction; diet; fatty acids; folate; neurogenesis; nutrients; polyphenols; thiamine; zinc; TRANSGENIC MOUSE MODEL; POLYUNSATURATED FATTY-ACIDS; NEURAL PROGENITOR CELLS; FOREBRAIN-SPECIFIC PRESENILIN-1; IMPAIRED ADULT NEUROGENESIS; PLACEBO-CONTROLLED TRIAL; BETA-AMYLOID PRODUCTION; GINKGO-BILOBA EXTRACT; B-VITAMIN TREATMENT; FACTOR G-CSF;

D O I：

10.3233/JAD-131004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.

引用

页码：11 / 38

页数：28

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