Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

被引：8
|
作者：
Wu, Li [1 ]
Li, Lu [1 ]
Wang, Fang [1 ]
Wu, Xianwei [1 ]
Zhao, Xin [1 ]
Xue, Na [1 ]
机构：
[1] Xi An Jiao Tong Univ, Honghui Hosp, Dept Anesthesia 2, Xian 710054, Shaanxi, Peoples R China
来源：
PHARMACOLOGY | 2019年 / 103卷 / 5-6期
关键词：
Inflammation; Cytokine; Nuclear factor-kappa B; Mitogen-activated protein kinases; Apoptosis; NITRIC-OXIDE; INFLAMMATORY RESPONSE; NITROUS-OXIDE; APOPTOSIS;
D O I：
10.1159/000496425
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present manuscript intended to investigate the anti-inflammatory effect of ropivacaine on lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E2, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1 beta, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2. Moreover, ropivacaine causes inhibition of mitogen-activated protein kinases as well as nuclear factor-kappa B signaling pathway and apoptosis in RAW 264.7 cells. Based on the results, it has been suggested that ropivacaine showed beneficial effect against inflammation. (c) 2019 S. Karger AG, Basel
引用
收藏
页码：228 / 235
页数：8
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