Tenofovir induced Fanconi syndrome: A possible pharmacokinetic interaction

被引:8
|
作者
Kapadia, Jigar [1 ]
Shah, Samidh [1 ]
Desai, Chetna [1 ]
Desai, Mira [1 ]
Patel, Shivani [2 ]
Shah, Asha N. [3 ,4 ]
Dikshit, R. K. [1 ]
机构
[1] BJ Med Coll, Dept Pharmacol, Ahmadabad, Gujarat, India
[2] BJ Med Coll, Dept Med, Ahmadabad, Gujarat, India
[3] Civil Hosp, Dept Med, Ahmadabad, Gujarat, India
[4] Civil Hosp, Nodal Officer ART Ctr, Ahmadabad, Gujarat, India
关键词
Adverse drug reaction; Fanconi syndrome; protease inhibitor; tenofovir; ADVERSE DRUG-REACTIONS; THERAPY;
D O I
10.4103/0253-7613.108319
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tenofovir was introduced as a second line drug for the treatment of human immunodeficiency virus (HIV) infection in India in December 2009. Although rare, renal toxicity is a recognized adverse drug reaction (ADR) of this drug, especially when administered with boosted lopinavir-ritonavir. In this case, an HIV positive patient receiving tenofovir based antiretroviral therapy (ART) for last 1 year developed albuminuria, glycosuria and hypophosphatemia. Renal function tests and random blood sugar were within normal limits. He was diagnosed as a case of tenofovir induced Fanconi syndrome. Tenofovir was discontinued and patient was prescribed an alternate regimen. Five months later clinical symptoms and renal functions returned to normal. A pharmacokinetic interaction between tenofovir and ritonavir may have resulted in the toxicity. A periodic monitoring of renal functions is desirable in patients on tenofovir based ART.
引用
收藏
页码:191 / 192
页数:2
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