Identification of circulating microRNAs as biomarkers in cancers: what have we got?

被引：25
|
作者：
Sun, Yu [1 ]
Zhang, Kuo [1 ]
Fan, Gaowei [1 ,2 ]
Li, Jinming [1 ,2 ]
机构：
[1] Beijing Hosp, Natl Ctr Clin Labs, Minist Hlth, Beijing 100730, Peoples R China
[2] Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China
来源：
CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2012年 / 50卷 / 12期
关键词：
biomarkers; cancer; circulating microRNAs; confounding factors; BREAST-CANCER; OVARIAN-CANCER; SERUM; PLASMA; EXPRESSION; DIAGNOSIS; RNAS;
D O I：
10.1515/cclm-2012-0360
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
During the past few years there has been great interest in the development of circulating microRNAs (miRNAs) as stable blood-based biomarkers for cancer detection. Deregulation of miRNAs in blood samples has shown considerable clinical utilities in cancers. Due to poorly characterized preanalytical and analytical variables and the lack of a standardized measurement protocol, the application of these miRNA fingerprints is hindered by conflicting results. In this review, we outline our current understanding of preanalytically and analytically confounding factors. We believe that great consideration should be taken in the development of circulating miRNA as tumor biomarkers.
引用
收藏
页码：2121 / 2126
页数：6
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