Synthesis and anti-cancer activity of GSK1720070: A novel small molecule inhibitor of AKT/PKB.

被引:0
|
作者
Verma, Sharad [1 ]
Safonov, Igor [1 ]
Lin, Hong [1 ]
Xie, Ren [1 ]
Zheng, Jin [1 ]
LaFrance, Louis [1 ]
Kahana, Jason [1 ]
Robell, Kim [1 ]
Zhang, ShuYun [1 ]
Choudhry, Anthony [1 ]
Minthorn, Elisabeth [1 ]
Yamashita, Dennis [1 ]
Kumar, Rakesh [1 ]
Heerding, Dirk [1 ]
机构
[1] GlaxoSmithKline, Collegeville, PA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2688
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs
    Wang, Hao-Meng
    Zhang, Li
    Liu, Jiang
    Yang, Zhao-Liang
    Zhao, Hong-Ye
    Yang, Yao
    Shen, Di
    Lu, Kui
    Fan, Zhen-Chuan
    Yao, Qing-Wei
    Zhang, Yong-Min
    Teng, Yu-Ou
    Peng, Yu
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 92 : 439 - 448
  • [42] Novel 2-pyridone Analogs with Anti-cancer Activity: Synthesis, In silico, and In vitro Evaluation
    Mishra, Prem Shankar
    Ravichandiran, Velayutham
    Mishra, Rakhi
    LETTERS IN DRUG DESIGN & DISCOVERY, 2024, 21 (07) : 1195 - 1207
  • [43] Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry
    Zhang, Yikai
    Lv, Zhiliang
    Zhong, Hanyu
    Geng, Dongping
    Zhang, Mingfeng
    Zhang, Tao
    Li, Yongmei
    Li, Ke
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 53 : 356 - 363
  • [44] A Novel Catalytic Synthesis of Flavones under Autoclave Conditions and Comparative Study of Anti-cancer Activity
    Rajeshbabu, K.
    Pushpalatha, S.
    Ramakrishna, B.
    Madhavarao, V.
    BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, 2016, 9 (01):
  • [45] Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer
    Zheng-hai TANG
    Wen-xiang CAO
    Xia GUO
    Xiao-yang DAI
    Jia-hong LU
    Xiu-ping CHEN
    Hong ZHU
    Jin-jian LU
    中国药理学与毒理学杂志, 2017, 31 (10) : 997 - 998
  • [46] Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer
    Tang, Zheng-Hai
    Cao, Wen-Xiang
    Guo, Xia
    Dai, Xiao-Yang
    Lu, Jia-Hong
    Chen, Xiuping
    Zhu, Hong
    Lu, Jin-Jian
    CANCER LETTERS, 2018, 412 : 1 - 9
  • [47] Triazine-based small molecule library screening yields a novel anti-cancer drug that blocks carcinoma invasion
    Kim, Jin Mi
    Jung, Da-Woon
    Che, Zhong Min
    Ha, Hyung-Ho
    Chang, Young-Tae
    Kim, Jin
    CANCER RESEARCH, 2009, 69
  • [48] Development of ROC-325: A Novel Small Molecule Inhibitor of Autophagy with Promising Anti-Leukemic Activity
    Nawrocki, Steffan T.
    Han, Yingchun
    Visconte, Valeria
    Phillips, James G.
    Przychodzen, Bartlomiej P.
    Maciejewski, Jaroslaw P.
    Kelly, Kevin R.
    Carew, Jennifer S.
    BLOOD, 2016, 128 (22)
  • [49] Synthesis of novel forskolin isoxazole derivatives with potent anti-cancer activity against breast cancer cell lines
    Burra, Srinivas
    Voora, Vani
    Rao, Ch. Prasad
    Kumar, P. Vijay
    Kancha, Rama Krishna
    Krupadanam, G. L. David
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (18) : 4314 - 4318
  • [50] Synthesis of some novel thiosemicarbazone derivatives having anti-cancer, anti-HIV as well as anti-bacterial activity
    Patel, Hitesh Dahyabhai
    Divatia, Saavani Malove
    de Clercq, Erik
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2013, 52 (04): : 535 - 545