MAGE-A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

被引：16
|
作者：
Gu, Lina [1 ]
Sang, Meixiang [1 ,2 ]
Yin, Danjing [1 ]
Liu, Fei [1 ]
Wu, Yunyan [1 ]
Liu, Shina [1 ]
Huang, Weina [1 ]
Shan, Baoen [1 ,2 ]
机构：
[1] Hebei Med Univ, Res Ctr, Hosp 4, 14 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China
[2] Hebei Med Univ, Tumor Res Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China
来源：
THORACIC CANCER | 2018年 / 9卷 / 04期
关键词：
Biological marker; lung cancer; MAGE; metastasis; prognosis; CIRCULATING TUMOR-CELLS; CLINICAL-SIGNIFICANCE; BREAST-CANCER; STATISTICS; ANTIGEN;
D O I：
10.1111/1759-7714.12571
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BackgroundMAGE-A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE-A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE-A in the peripheral blood of patients with lung cancer. MethodsIn this study, we detected MAGE-A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi-nested PCR and analyzed their correlation with clinicopathological risk factors. ResultsMAGE-A expression was associated with factors indicating poor prognosis. The expression of MAGE-A and each individual MAGE-A gene were also associated with low overall survival in patients with lung cancer. ConclusionThe expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.
引用
收藏
页码：431 / 438
页数：8
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