The cloned locus of enterocyte effacement from enterohemorrhagic Escherichia coli O157:H7 is unable to confer the attaching and effacing phenotype upon E-coli K-12

被引：84
|
作者：
Elliott, SJ
Yu, J
Kaper, JB
机构：
[1] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 08期
关键词：
D O I：
10.1128/IAI.67.8.4260-4263.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The locus of enterocyte effacement (LEE) pathogenicity island of enterohemorrhagic Escherichia coli (EREC) O157:H7 possesses the same genes in identical order and orientation as the LEE of enteropathogenic E. coli (EPEC) O127:H6 but is unable to form attaching and effacing (A/E) lesions or to secrete Esp proteins when it is cloned in an E. call K-12 background, The A/E phenotype could not be restored by trans complementation with a variety of cloned EPEC LEE fragments, suggesting functional and/or regulatory differences between the LEE pathogenicity islands of EPEC O127:H6 and EHEC O157:H7.
引用
收藏
页码：4260 / 4263
页数：4
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