Antimutagenic and antioxidant activity of Lisosan G in Saccharomyces cerevisiae

被引：27

作者：

Frassinetti, Stefania ^{[1
]}

Della Croce, Clara Maria ^{[1
]}

Caltavuturo, Leonardo ^{[1
]}

Longo, Vincenzo ^{[1
]}

机构：

[1] CNR, Inst Biol & Agr Biotechnol IBBA, Pisa Unit, Res Area Pisa, I-56124 Pisa, Italy

来源：

FOOD CHEMISTRY | 2012年 / 135卷 / 03期

关键词：

Lisosan G; Genotoxicity; Saccharomyces cerevisiae; Oxidative stress; ORAC; WHOLE-GRAIN; YEAST; CANCER; BRAN; ACID;

D O I：

10.1016/j.foodchem.2012.06.090

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In the present study the antimutagenic and antioxidant effects of a powder of grain (Lisosan G) in yeast Saccharomyces cerevisiae were studied. Results showed that Lisosan G treatment decreased significantly the intracellular ROS concentration and mutagenesis induced by hydrogen peroxide in S. cerevisiae D7 strain. The effect of Lisosan G was then evaluated by using superoxide dismutase (SOD) proficient and deficient strains of S. cerevisiae. Lisosan G showed protective activity in sod1 Delta and sod2 Delta mutant strains, indicating an in vivo antioxidant effect. A high radical scavenging activity of Lisosan G was also demonstrated in vitro using the oxygen radical absorbance capacity (ORAC) assay. The obtained results showed a protective effect of Lisosan G in yeast cells, indicating that its antioxidant capacity contributes to its antimutagenic action. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2029 / 2034

页数：6

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