Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

被引：890

作者：

Ferreira, Manuel A. R. ^{[1
,2
,3
,4
,5
,6
]}

O'Donovan, Michael C. ^{[7
]}

Meng, Yan A. ^{[1
,2
,3
,4
,5
]}

Jones, Ian R. ^{[7
]}

Ruderfer, Douglas M. ^{[1
,3
,4
,5
]}

Jones, Lisa ^{[8
]}

Fan, Jinbo ^{[1
,3
,4
,5
]}

Kirov, George ^{[7
]}

Perlis, Roy H. ^{[1
,3
,4
,5
]}

Green, Elaine K. ^{[7
]}

Smoller, Jordan W. ^{[2
,4
,5
]}

Grozeva, Detelina ^{[7
]}

Stone, Jennifer ^{[1
,2
,3
,4
,5
]}

Nikolov, Ivan ^{[7
,9
]}

Chambert, Kimberly ^{[4
,5
]}

Hamshere, Marian L. ^{[7
,9
]}

Nimgaonkar, Vishwajit L. ^{[10
]}

Moskvina, Valentina ^{[7
,9
]}

Thase, Michael E. ^{[11
,12
]}

Caesar, Sian ^{[8
]}

Sachs, Gary S. ^{[1
,2
]}

Franklin, Jennifer

Gordon-Smith, Katherine ^{[8
]}

Ardlie, Kristin G. ^{[4
,5
]}

Gabriel, Stacey B. ^{[4
,5
]}

Fraser, Christine ^{[7
]}

Blumenstiel, Brendan ^{[4
,5
]}

Defelice, Matthew ^{[4
,5
]}

Breen, Gerome ^{[13
,14
]}

Gill, Michael ^{[15
]}

Morris, Derek W. ^{[15
]}

Elkin, Amanda ^{[14
]}

Muir, Walter J. ^{[16
]}

McGhee, Kevin A. ^{[16
]}

Williamson, Richard ^{[14
]}

MacIntyre, Donald J. ^{[16
]}

MacLean, Alan W. ^{[16
]}

Clair, David St ^{[13
]}

Robinson, Michelle ^{[17
]}

Van Beck, Margaret ^{[16
]}

Pereira, Ana C. P. ^{[17
]}

Kandaswamy, Radhika ^{[17
]}

McQuillin, Andrew ^{[17
]}

Collier, David A. ^{[14
]}

Bass, Nicholas J. ^{[17
]}

Young, Allan H. ^{[18
,19
]}

Lawrence, Jacob ^{[17
]}

Ferrier, I. Nicol ^{[18
]}

Anjorin, Adebayo ^{[17
]}

Farmer, Anne

机构：

[1] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[3] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Ctr Human Genet Res, Boston, MA 02114 USA

[4] Harvard Univ, Stanley Ctr Psychiat Res, Broad Inst, Cambridge, MA 02142 USA

[5] MIT, Cambridge, MA 02142 USA

[6] Queensland Inst Med Res, Brisbane, Qld 4029, Australia

[7] Cardiff Univ, Sch Med, Dept Psychol Med, Cardiff CF14 4XN, England

[8] Univ Birmingham, Div Neurosci, Dept Psychiat, Birmingham B15 2QZ, England

[9] Cardiff Univ, Sch Med, Biostat & Bioinformat Unit, Cardiff CF14 4XN, England

[10] Univ Pittsburgh, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA

[11] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[12] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15213 USA

[13] Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

[14] Kings Coll London, Inst Psychiat, SGDP, London SE5 8AF, England

[15] St James Hosp, Trinity Coll, Trinity Ctr hlth Sci, Dublin 8, Ireland

[16] Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland

[17] UCL, Windeyer Inst Med Sci, Dept Mental Hlth Sci, Mol Psychiat Lab, London W1T 4JF, England

[18] Royal Victoria Infirm, Sch Neurol Neurolbiol & Psychiat, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[19] UBC, Inst Mental Hlth, Vancouver, BC V6T 2A1, Canada

[20] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[21] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[22] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[23] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 09期

基金：

英国医学研究理事会; 爱尔兰科学基金会; 英国惠康基金;

关键词：

D O I：

10.1038/ng.209

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

引用

页码：1056 / 1058

页数：3

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