A novel asymmetric synthesis of cinacalcet hydrochloride

被引：17
|
作者：
Arava, Veera R. [1 ]
Gorentla, Laxminarasimhulu [1 ]
Dubey, Pramod K. [2 ]
机构：
[1] Suven Life Sci Ltd, R&D Lab, Hyderabad, Andhra Pradesh, India
[2] JNT Univ, Dept Chem, Hyderabad, Andhra Pradesh, India
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 8卷
关键词：
asymmetric synthesis; (R)-tert-butanesulfinamide; cinacalcet hydrochloride; naphthyl ethyl sulfinamide; regioselective N-alkylation; CALCIMIMETIC AGENT; REDUCTION; AMINES;
D O I：
10.3762/bjoc.8.158
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel route to asymmetric synthesis of cinacalcet hydrochloride by the application of (R)-tert-butanesulfinamide and regioselective N-alkylation of the naphthyl ethyl sulfinamide intermediate is described.
引用
收藏
页码：1366 / 1373
页数：8
相关论文
共 50 条
  • [21] Pharmacokinetics of Cinacalcet Hydrochloride When Administered with Ketoconazole
    Robert Z. Harris
    Margaret Salfi
    John T. Sullivan
    Desmond Padhi
    Clinical Pharmacokinetics, 2007, 46 : 495 - 501
  • [22] Cinacalcet hydrochloride - A viewpoint by Pablo Urena Torres
    Torres, PU
    DRUGS, 2005, 65 (02) : 282 - 283
  • [23] Clinical Pharmacokinetic and Pharmacodynamic Profile of Cinacalcet Hydrochloride
    Padhi, Desmond
    Harris, Robert
    CLINICAL PHARMACOKINETICS, 2009, 48 (05) : 303 - 311
  • [24] A novel synthesis of difloxacin hydrochloride
    Dai, LY
    Chen, YQ
    CHINESE CHEMICAL LETTERS, 2001, 12 (10) : 875 - 876
  • [25] A Novel Synthesis of Difloxacin Hydrochloride
    Li Yan DAI*
    Chinese Chemical Letters, 2001, (10) : 875 - 876
  • [26] Management of lithium-associated hyperparathyroidism with cinacalcet hydrochloride
    Craus, Sarah
    Mifsud, Emma L.
    Mifsud, Simon
    Vella, Sandro
    BRITISH JOURNAL OF HOSPITAL MEDICINE, 2023, 84 (01)
  • [27] Release Behavior of Cinacalcet Hydrochloride Using Wet Granulation
    Lee, Ji Eun
    Been, Suyoung
    Choi, Jeongmin
    Cho, Hunhwi
    Kim, Namyeong
    Song, Jeong Eun
    Khang, Gilson
    POLYMER-KOREA, 2021, 45 (01) : 16 - 21
  • [28] Cinacalcet Hydrochloride Therapy for Secondary Hyperparathyroidism in Hemodialysis Patients
    El-Shafey, Eid M.
    Alsahow, Ali E.
    Alsaran, Khalid
    Sabry, Alaa A.
    Atia, Mohamed
    THERAPEUTIC APHERESIS AND DIALYSIS, 2011, 15 (06) : 547 - 555
  • [29] An Improved Process for Synthesis of (S)-Duloxetine Hydrochloride Involving Enzymatic Asymmetric Carbonyl Reduction on a Novel Ketoamine
    Sasane, Sachin A.
    Husain, Mofazzal
    Bhise, Nandu B.
    Singh, Girij P.
    Joseph, Alex
    Shenoy, Gautham G.
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2020, 53 (01) : 1 - 8
  • [30] Cinacalcet hydrochloride reduces hypercalcemia in patients with parathyroid carcinoma
    不详
    Nature Clinical Practice Endocrinology & Metabolism, 2007, 3 (12): : 794 - 794
12345