Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population

Background Type 2 diabetes mellitus (T2DM), one of the global health issues, is a group of metabolic diseases and is affected by several genetic loci in the clinical phenotype. This study intended to ascertain associations betweenCYP19A1andCYP1A2gene polymorphisms with the T2DM risk in Chinese Han. Methods Seven single nucleotide polymorphisms (SNPs) in total including five ofCYP19A1(rs4646, rs6493487, rs1062033, rs17601876 and rs3751599) and two ofCYP1A2(rs762551 and rs2470890) from 512 T2DM patients and 515 non-diabetic controls were genotyped in the platform of Agena MassARRAY. SPSS 18.0 was utilized for analyzing genotyping results. Logistic regression models were conducted for the risk assessment by the odds ratios (ORs) and 95% confidence intervals (CIs). Results The results suggested a significant association between genotype GC of rs1062033 with a decreased T2DM risk (OR = 0.73, 95% CI = 0.55-0.96,P = 0.025) under the co-dominant (heterozygous) model. The results of stratification analysis with age and gender adjustment revealed that the effects of all selected SNPs inCYP19A1andCYP1A2on the T2DM susceptibility were dependent on age, body mass index (BMI) and disease progression (P < 0.05). The haplotype analysis was further conducted and the results indicated that C(rs1062033)G(rs17601876)A(rs3751599)inCYP19A1played a protective role (OR = 0.48, 95% CI = 0.25-0.91,P = 0.026) in T2DM patients with diabetic retinopathy. Conclusion This population-based case-control study suggested thatCYP19A1andCYP1A2variations might affect the susceptibility of T2DM. The findings provide a theoretical basis for searching the clinical therapeutic markers and attractive drug targets of T2DM.