Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to PPAR-γ activation in mice with chronic cerebral hypoperfusion

被引:0
|
作者
Washida, Kazuo [1 ]
Ihara, Masafumi [1 ]
Nishio, Keiko [1 ]
Fujita, Youshi [1 ]
Maki, Takakuni [1 ]
Yamada, Mahito [1 ]
Takahashi, Jun [3 ]
Wu, Xiaofeng [4 ]
Kihara, Takeshi [4 ]
Ito, Hidefumi [1 ]
Tomimoto, Hidekazu [2 ]
Takahashi, Ryosuke [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Dept Neurol, Kyoto 6068501, Japan
[2] Mie Univ, Grad Sch Med, Dept Neurol, Tsu, Mie, Japan
[3] Kyoto Univ, Inst Frontier Med Sci, Dept Biol Repair, Kyoto 6068501, Japan
[4] Kyoto Univ, Grad Sch Phamaceut Sci, Dept Neurosci Drug Discovery Res, Kyoto 6068501, Japan
关键词
D O I
10.1016/j.neures.2010.07.1342
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:E302 / E302
页数:1
相关论文
共 33 条
  • [21] dl-3-n-butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion
    Han, Qin-Yu
    Zhang, He
    Zhang, Xi
    He, Dong-Sheng
    Wang, Sun-Wei
    Cao, Xiang
    Dai, Yu-Tian
    Xu, Yun
    Han, Li-Juan
    CNS NEUROSCIENCE & THERAPEUTICS, 2019, 25 (09) : 1042 - 1053
  • [22] Spatial Memory Impairment in Amyloid Beta-injected Mice was Improved by Treatment with an Angiotensin II Receptor Antagonist, Telmisartan Partly due to PPARγ Activation
    Tsukuda, Kana
    Mogi, Masaki
    Iwanami, Jun
    Li, Jian-Mei
    Min, Li-Juan
    Fujita, Teppei
    Salkata, Akiko
    Iwai, Masaru
    Horiuchi, Masatsugu
    STROKE, 2009, 40 (04) : E276 - E276
  • [23] MCP-1-mediated activation of microglia promotes white matter lesions and cognitive deficits by chronic cerebral hypoperfusion in mice
    Yuan, Bangqing
    Shi, Hui
    Zheng, Kuang
    Su, Zulu
    Su, Hai
    Zhong, Ming
    He, Xuenong
    Zhou, Changlong
    Chen, Hao
    Xiong, Qijiang
    Zhang, Yi
    Yang, Zhao
    MOLECULAR AND CELLULAR NEUROSCIENCE, 2017, 78 : 52 - 58
  • [24] HMGB1 Neutralization Attenuates Hippocampal Neuronal Death and Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion via Suppressing Inflammatory Responses and Oxidative Stress
    Hei, Yue
    Chen, Rong
    Yi, Xicai
    Long, Qianfa
    Gao, Dakuan
    Liu, Weiping
    NEUROSCIENCE, 2018, 383 : 150 - 159
  • [25] Tetrandrine ameliorates cognitive impairment via inhibiting astrocyte-derived S100B activation in a rat model of chronic cerebral hypoperfusion
    Chen, Lianlian
    Chen, Lixue
    Lv, Yanling
    Cui, Zhiwei
    Bei, Gui
    Qin, Guangcheng
    Zhou, Jiying
    Ge, Tan
    NEUROLOGICAL RESEARCH, 2013, 35 (06) : 614 - 621
  • [26] Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice
    Yoshizaki, Kaichi
    Adachi, Kayo
    Kataoka, Seiko
    Watanabe, Atsushi
    Tabira, Takeshi
    Takahashi, Keikichi
    Wakita, Hideaki
    EXPERIMENTAL NEUROLOGY, 2008, 210 (02) : 585 - 591
  • [27] Microbial lipopolysaccharide-induced inflammation contributes to cognitive impairment and white matter lesion progression in diet-induced obese mice with chronic cerebral hypoperfusion
    Inaba, Toshiki
    Yamashiro, Kazuo
    Kurita, Naohide
    Ueno, Yuji
    Miyamoto, Nobukazu
    Hira, Kenichiro
    Nakajima, Sho
    Kijima, Chikage
    Nakaguro, Ryohei
    Urabe, Takao
    Hattori, Nobutaka
    CNS NEUROSCIENCE & THERAPEUTICS, 2023, : 200 - 212
  • [28] Microglial activation, white matter and hippocampal damage correlate with cognitive impairment in chronic cerebral hypoperfused and MPTP-lesioned mice
    Gao, Y.
    Tang, H.
    Nie, K.
    Zhu, R.
    Gao, L.
    Feng, S.
    Wang, L.
    Zhao, J.
    Huang, Z.
    Zhang, Y.
    Wang, L.
    MOVEMENT DISORDERS, 2018, 33 : S811 - S815
  • [29] The Alpha-7 Nicotinic Receptor Positive Allosteric Modulator PNU120596 Attenuates Lipopolysaccharide-Induced Depressive-Like Behaviors and Cognitive Impairment by Regulating the PPAR-α Signaling Pathway in Mice
    Alzarea, Sami
    Rahman, Shafiqur
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2025, 24 (03) : 234 - 244
  • [30] Fo-Shou-San Ameliorates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment in Mice by Regulating NRF2/HO-1 Pathway Against Ferroptosis
    Wang, Jueyu
    Shi, Jiahui
    Xiao, Yinfang
    Chen, Gongcan
    Yang, Cong
    Duan, Lining
    Zhao, Wei
    Wang, Qi
    JOURNAL OF INTEGRATIVE NEUROSCIENCE, 2023, 22 (02)