Polycomb in Stem Cells: PRC1 Branches Out

被引：53
|
作者：
Miguel Luis, Nuno [1 ,2 ]
Morey, Lluis [1 ,2 ]
Di Croce, Luciano [1 ,2 ,3 ]
Aznar Benitah, Salvador [1 ,2 ]
机构：
[1] CRG, Barcelona 08003, Spain
[2] UPF, Barcelona 08003, Spain
[3] ICREA, Barcelona 08010, Spain
来源：
CELL STEM CELL | 2012年 / 11卷 / 01期
关键词：
SELF-RENEWAL; HEMATOPOIETIC STEM; CHROMATIN-STRUCTURE; SMALL-INTESTINE; PROTEINS; GENES; BMI-1; PROLIFERATION; MAINTENANCE; CBX7;
D O I：
10.1016/j.stem.2012.06.005
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.
引用
收藏
页码：16 / 21
页数：6
相关论文
共 50 条
  • [21] Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity
    Chiacchiera, Fulvio
    Rossi, Alessandra
    Jammula, SriGanesh
    Piunti, Andrea
    Scelfo, Andrea
    Ordonez-Moran, Paloma
    Huelsken, Joerg
    Koseki, Haruhiko
    Pasini, Diego
    CELL STEM CELL, 2016, 18 (01) : 91 - 103
  • [22] Polycomb Repressor Complex 1 (PRC1) in ovarian cancer: A scoping literature review
    Floyd, Jessica
    DeSanto, Kristen
    Bitler, Benjamin G.
    Brubaker, Lindsay W.
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2024, 202
  • [23] Polycomb repressive complex 1 (PRC1) regulates meiotic initiation of ovarian germ cells in chick embryos
    Tang, Xiaochuan
    Xu, Shiyong
    Li, Rongyang
    Zhang, Hongpeng
    Chen, Qing
    Wu, Wangjun
    Liu, Honglin
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2016, 437 (0C) : 171 - 182
  • [24] Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice
    Rossi, Alessandra
    Ferrari, Karin J.
    Piunti, Andrea
    Jammula, SriGanesh
    Chiacchiera, Fulvio
    Mazzarella, Luca
    Scelfo, Andrea
    Pelicci, Pier Giuseppe
    Pasini, Diego
    SCIENCE ADVANCES, 2016, 2 (10):
  • [25] THE REGULATORY ROLE OF POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) IN INFLAMMATORY BOWEL DISEASE
    Gonzalez, Michelle
    Svingen, Phyllis
    Sarmento, Olga F.
    Smyrk, Thomas
    Sagstetter, Mary R.
    Bamidele, Adebowale O.
    Neto, Manuel Bonfim Braga
    Ramos, Guilherme Piovezani
    Gaballa, Joseph M.
    Kerketta, Romica
    Urrutia, Raul
    Faubion, William
    GASTROENTEROLOGY, 2019, 156 (06) : S870 - S871
  • [26] Genome-wide profiling of PRC1 and PRC2 polycomb chromatin binding in Drosophila melanogaster
    Tolhuis, Bas
    Muijrers, Inhua
    de Wit, Elzo
    Teunissen, Hans
    Talhout, Wendy
    van Steensel, Bas
    van Lohuizen, Maarten
    NATURE GENETICS, 2006, 38 (06) : 694 - 699
  • [27] Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster
    Bas Tolhuis
    Inhua Muijrers
    Elzo de Wit
    Hans Teunissen
    Wendy Talhout
    Bas van Steensel
    Maarten van Lohuizen
    Nature Genetics, 2006, 38 : 694 - 699
  • [28] Uncoupled evolution of the Polycomb system and deep origin of non-canonical PRC1
    Bastiaan de Potter
    Maximilian W. D. Raas
    Michael F. Seidl
    C. Peter Verrijzer
    Berend Snel
    Communications Biology, 6
  • [29] The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation
    Boukarabila, Hanane
    Saurin, Andrew J.
    Batsche, Eric
    Mossadegh, Noushine
    van Lohuizen, Maarten
    Otte, Arie P.
    Pradel, Jacques
    Muchardt, Christian
    Sieweke, Michael
    Duprez, Estelle
    GENES & DEVELOPMENT, 2009, 23 (10) : 1195 - 1206
  • [30] LEUKEMIC TRANSFORMATION BY PLZF/RARA IS MEDIATED BY THE RECRUITMENT OF THE PRC1 POLYCOMB GROUP COMPLEX
    Duprez, E.
    Boukarabila, A.
    Saurin, J.
    Batshe, E.
    Mosadegh, N.
    Otte, P.
    Pradel, J.
    Muchardt, C.
    Sieweke, H.
    Duprez, A.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 372 - 373
12345