Polycomb in Stem Cells: PRC1 Branches Out

被引：53

作者：

Miguel Luis, Nuno ^{[1
,2
]}

Morey, Lluis ^{[1
,2
]}

Di Croce, Luciano ^{[1
,2
,3
]}

Aznar Benitah, Salvador ^{[1
,2
]}

机构：

[1] CRG, Barcelona 08003, Spain

[2] UPF, Barcelona 08003, Spain

[3] ICREA, Barcelona 08010, Spain

来源：

CELL STEM CELL | 2012年 / 11卷 / 01期

关键词：

SELF-RENEWAL; HEMATOPOIETIC STEM; CHROMATIN-STRUCTURE; SMALL-INTESTINE; PROTEINS; GENES; BMI-1; PROLIFERATION; MAINTENANCE; CBX7;

D O I：

10.1016/j.stem.2012.06.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.

引用

页码：16 / 21

页数：6

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