Successful treatment of a case of relapsed acute promyelocytic leukemia with arsenic trioxide

被引:1
|
作者
Hirayama, Y [1 ]
Koyama, R [1 ]
Nagai, T [1 ]
Ohta, H [1 ]
Kondo, A [1 ]
Ishikawa, K [1 ]
Ishitani, K [1 ]
Matsunaga, T [1 ]
Sakamaki, S [1 ]
Niitsu, Y [1 ]
机构
[1] Hokkaido Prefectural Sapporo Kitano Hosp, Sapporo, Hokkaido, Japan
关键词
ATRA; skin erythema; neuralgia;
D O I
10.2169/internalmedicine.40.1136
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report a patient with an initial relapse of acute promyelocytic leukemia (APL) who achieved a second complete remission (CR) after treatment with arsenic trioxide. The patient, a 66-year-old woman diagnosed as having relapsed APL, received arsenic trioxide intravenously at a dose of 10 mg/day. At day 36, the patient achieved a second CR. The side effects were slight neuralgia and mild skin erythematous changes, which improved following cessation of the drug. Although arsenic trioxide may be effective for relapsed APL, it should be used with caution because of various complications.
引用
收藏
页码:1136 / 1139
页数:4
相关论文
共 50 条
  • [41] Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia
    Agis, H
    Weltermann, A
    Mitterbauer, G
    Thalhammer, R
    Edelhäuser, M
    Seewann, HL
    Valent, P
    Lechner, K
    Fonatsch, C
    Geissler, K
    ANNALS OF HEMATOLOGY, 1999, 78 (07) : 329 - 332
  • [42] Acute intestinal pseudo-obstruction after induction treatment of relapsed acute promyelocytic leukemia with arsenic trioxide
    Park, Jeong A.
    Yun, Jong Hyung
    Kang, Hyoung In
    Shin, Hee Young
    Ahn, Hyo Seop
    PEDIATRIC BLOOD & CANCER, 2008, 50 (04) : 872 - 874
  • [43] Carcinogenic risk of retained arsenic after successful treatment of acute promyelocytic leukemia with arsenic trioxide: a cause for concern?
    Firkin, Frank
    LEUKEMIA & LYMPHOMA, 2014, 55 (05) : 977 - 978
  • [44] Relapsed acute promyelocytic leukemia in a hemodialysis-dependent patient treated with arsenic trioxide: A case report
    Emmons G.S.
    Steingart R.H.
    Stewart J.A.
    Mertens W.C.
    Journal of Medical Case Reports, 6 (1)
  • [45] COST-EFFECTIVENESS OF ARSENIC TRIOXIDE IN THE TREATMENT OF RELAPSED/REFRACTORY ACUTE PROMYELOCYTIC LYMPHOMA LEUKEMIA IN CANADA
    Lachaine, J.
    Mathurin, K.
    Barakat, S.
    VALUE IN HEALTH, 2014, 17 (03) : A84 - A84
  • [46] Role of Arsenic Trioxide in Acute Promyelocytic Leukemia
    Iland, Harry J.
    Seymour, John F.
    CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2013, 14 (02) : 170 - 184
  • [47] Arsenic trioxide: Acute promyelocytic leukemia and beyond
    Bachleitner-Hofmann, T
    Kees, M
    Gisslinger, H
    LEUKEMIA & LYMPHOMA, 2002, 43 (08) : 1535 - 1540
  • [48] Parenthood in patients with acute promyelocytic leukemia after treatment with arsenic trioxide: a case series
    Gupta, Shilpa
    Bagel, Bhausaheb
    Gujral, Sumeet
    Subramanian, P. G.
    Khattry, Navin
    Menon, Hari
    Nair, Reena
    LEUKEMIA & LYMPHOMA, 2012, 53 (11) : 2192 - 2194
  • [49] Role of Arsenic Trioxide in Acute Promyelocytic Leukemia
    Harry J. Iland
    John F. Seymour
    Current Treatment Options in Oncology, 2013, 14 : 170 - 184
  • [50] Use of arsenic trioxide in a hemodialysis-dependent patient with relapsed acute promyelocytic leukemia
    Perreault, Sarah
    Moeller, Julie
    Patel, Kejal
    Eyler, Rachel
    Pham, Trinh
    Russell, Kerry
    Podoltsev, Nikolai
    JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2016, 22 (04) : 646 - 651