Since the discovery of the influence of the endocrine system on cardiac endocrine function 30 years ago, an increasing number of experimental and clinical studies have consolidated endocrine function of human heart as being a relevant component of a complex network including endocrine, nervous and immune systems. Many aspects, however, still remain unclear as to the production, secretion and peripheral degradation pathways of B- and C-type natriuretic peptides. In particular, the hypothesis that the circulating plasma pool of the pro-hormone can function as precursor of the active peptide hormone is yet to be fully demonstrated. According to recent studies, peripheral processing of circulating pro-hormone likely undergoes regulation pathways which seem to be impaired in patients with heart failure. This would open new perspectives also in the treatment of heart failure, and identify novel pharmacological targets for drugs inducing and/or modulating the maturation of the pro-hormone into active hormone. (C) 2013 Elsevier Ltd. All rights reserved.
机构:
Univ Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Iwaz, James A.
Lee, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Lee, Elizabeth
Aramin, Hermineh
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Aramin, Hermineh
Romero, Danilo
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Romero, Danilo
Iqbal, Navaid
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Iqbal, Navaid
Kawahara, Matt
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Kawahara, Matt
Khusro, Fatima
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Khusro, Fatima
Knight, Brian
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Knight, Brian
Patel, Minal V.
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Patel, Minal V.
Sharma, Sumita
论文数: 0引用数: 0
h-index: 0
机构:
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
Sharma, Sumita
Maisel, Alan S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA
VA San Diego Healthcare Syst, Vet Affairs Med Ctr, San Diego, CA 92161 USAUniv Calif San Diego, San Diego Med Ctr, San Diego, CA 92103 USA