Recent advances on natriuretic peptide system: New promising therapeutic targets for the treatment of heart failure

被引:27
|
作者
Del Ry, Silvia [1 ]
Cabiati, Manuela [1 ]
Clerico, Aldo [2 ,3 ]
机构
[1] CNR, Inst Clin Physiol, Lab Cardiovasc Biochem, I-56124 Pisa, Italy
[2] Scuola Superiore Santanna, Pisa, Italy
[3] Fdn G Monasterio CNR Regione Toscana, Dept Lab Med, Pisa, Italy
关键词
Natriuretic peptides; Cardiac endocrine function; BNP; CNP; Heart failure; RECEPTOR NPR-B; CIRCULATING FORMS; HUMAN-LEUKOCYTES; MOLECULAR-FORMS; NT-PROBNP; CD-NP; EXPRESSION; ATRIAL; CNP; IDENTIFICATION;
D O I
10.1016/j.phrs.2013.08.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Since the discovery of the influence of the endocrine system on cardiac endocrine function 30 years ago, an increasing number of experimental and clinical studies have consolidated endocrine function of human heart as being a relevant component of a complex network including endocrine, nervous and immune systems. Many aspects, however, still remain unclear as to the production, secretion and peripheral degradation pathways of B- and C-type natriuretic peptides. In particular, the hypothesis that the circulating plasma pool of the pro-hormone can function as precursor of the active peptide hormone is yet to be fully demonstrated. According to recent studies, peripheral processing of circulating pro-hormone likely undergoes regulation pathways which seem to be impaired in patients with heart failure. This would open new perspectives also in the treatment of heart failure, and identify novel pharmacological targets for drugs inducing and/or modulating the maturation of the pro-hormone into active hormone. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:190 / 198
页数:9
相关论文
共 50 条
  • [41] Brain natriuretic peptide and heart failure
    Terestchenko, SN
    Pavlikova, EP
    Meray, IA
    Moiseev, VS
    KARDIOLOGIYA, 2002, 42 (08) : 57 - 62
  • [42] Brain Natriuretic Peptide Biomarkers in Current Clinical and Therapeutic Scenarios of Heart Failure
    Alcidi, Gianmarco
    Goffredo, Giovanni
    Correale, Michele
    Brunetti, Natale Daniele
    Iacoviello, Massimo
    JOURNAL OF CLINICAL MEDICINE, 2022, 11 (11)
  • [43] Natriuretic peptide receptor c - could it be the next therapeutic target in heart failure?
    Kodziszewska, K. Katarzyna
    Leszek, P.
    Sochanowicz, B.
    EUROPEAN JOURNAL OF HEART FAILURE, 2017, 19 : 600 - 600
  • [44] NEW NEUROHORMONAL ANTAGONISTS AND ATRIAL-NATRIURETIC-PEPTIDE IN THE TREATMENT OF CONGESTIVE-HEART-FAILURE
    ABRAHAM, WT
    CORONARY ARTERY DISEASE, 1994, 5 (02) : 127 - 136
  • [45] Natriuretic Peptide System and the Heart
    Del Ry, Silvia
    Cabiati, Manuela
    Clerico, Aldo
    CARDIOVASCULAR ISSUES IN ENDOCRINOLOGY, 2014, 43 : 134 - 143
  • [47] Thematic review series IX: New therapeutic targets for the treatment of heart failure - Introduction
    Ross, J
    PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, 1999, 111 (05) : 396 - 398
  • [48] New Targets in the Drug Treatment of Heart Failure
    James A. Iwaz
    Elizabeth Lee
    Hermineh Aramin
    Danilo Romero
    Navaid Iqbal
    Matt Kawahara
    Fatima Khusro
    Brian Knight
    Minal V. Patel
    Sumita Sharma
    Alan S. Maisel
    Drugs, 2016, 76 : 187 - 201
  • [49] New Targets in the Drug Treatment of Heart Failure
    Iwaz, James A.
    Lee, Elizabeth
    Aramin, Hermineh
    Romero, Danilo
    Iqbal, Navaid
    Kawahara, Matt
    Khusro, Fatima
    Knight, Brian
    Patel, Minal V.
    Sharma, Sumita
    Maisel, Alan S.
    DRUGS, 2016, 76 (02) : 187 - 201
  • [50] Cardiorenal interactions in heart failure: insights from recent therapeutic advances
    Damman, Kevin
    Testani, Jeffrey
    CARDIOVASCULAR RESEARCH, 2024, 120 (12) : 1372 - 1384