A new coiled hollow-fiber module design for enhanced microfiltration performance in biotechnology

被引:0
|
作者
Luque, S
Mallubhotla, H
Gehlert, G
Kuriyel, R
Dzengeleski, S
Pearl, S
Belfort, G [1 ]
机构
[1] Rensselaer Polytech Inst, Howard P Isermann Dept Chem Engn, Troy, NY 12180 USA
[2] Millipore Corp, Bioproc Div, Bedford, MA 01730 USA
[3] Univ Oviedo, Dept Chem & Environm Technol, E-33071 Oviedo, Spain
[4] Tech Univ Hamburg Harburg, Dept Chem Engn, Hamburg, Germany
关键词
microfiltration; Dean vortices; helical hollow-fiber module; yeast suspension; E. coli lysate; mammalian cell culture; biotechnology;
D O I
10.1002/(SICI)1097-0290(19991105)65:3<247::AID-BIT1>3.3.CO;2-8
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The microfiltration performance of a novel membrane module design with helically wound hollow fibers is compared with that obtained with a standard commercial-type crossflow module containing linear hollow fibers. Cell suspensions (yeast, E. coli, and mammalian cell cultures) commonly clarified in the biotechnology industry are used for this comparison. The effect of variables such as transmembrane pressure, particle suspension concentration, and feed flow rate on membrane performance is evaluated. Normalized permeation fluxes versus flow rate or Dean number behave according to a heat transfer correlation obtained with centrifugal instabilities of the Taylor type. The microfiltration performance of this new module design, which uses secondary flows in helical tubes, is significantly better than an equivalent current commercial crossflow module when filtering suspensions relevant to the biotechnology industry. Flux and capacity improvements of up to 3.2-fold (constant transmembrane pressure operation) and 3.9-fold (constant flux operation), respectively, were obtained with the helical module over those for the linear module. (C) 1999 John Wiley & Sons, Inc.
引用
收藏
页码:247 / 257
页数:11
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