The Emerging Role of MicroRNA-155 in Cardiovascular Diseases

被引：44
|
作者：
Cao, Richard Y. [1 ]
Li, Qing [2 ]
Miao, Yi [3 ]
Zhang, Ying [2 ]
Yuan, Wenchao [2 ]
Fan, Li [2 ]
Liu, Gongliang [2 ]
Mi, Qiongyao [4 ]
Yang, Jian [2 ]
机构：
[1] Fudan Univ, Shanghai Zhongshan Xuhui Hosp, Shanghai Clin Res Ctr,Chinese Acad Sci, Lab Immunol,Shanghai Xuhui Cent Hosp, 966 Middle Huaihai Rd, Shanghai 200031, Peoples R China
[2] Fudan Univ, Shanghai Zhongshan Xuhui Hosp, Shanghai Clin Res Ctr,Chinese Acad Sci, Dept Rehabil,Shanghai Xuhui Cent Hosp, Shanghai 200031, Peoples R China
[3] Fudan Univ, Shanghai Zhongshan Xuhui Hosp, Shanghai Clin Res Ctr,Chinese Acad Sci, Clin Lab,Shanghai Xuhui Cent Hosp, 966 Middle Huaihai Rd, Shanghai 200031, Peoples R China
[4] Shanghai Univ, Sch Life Sci, 99 Shangda Rd, Shanghai 200444, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2016年 / 2016卷
基金：
中国国家自然科学基金;
关键词：
ABDOMINAL AORTIC-ANEURYSMS; FOAM CELL-FORMATION; CIRCULATING MICRORNAS; HEART-FAILURE; EXPRESSION; ATHEROSCLEROSIS; DYSFUNCTION; MECHANISM; MIR-155; DEATH;
D O I：
10.1155/2016/9869208
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
MicroRNAs have been demonstrated to be involved in human diseases, including cardiovascular diseases. Growing evidences suggest that microRNA-155, a typical multifunctional microRNA, plays a crucial role in hematopoietic lineage differentiation, immunity, inflammation, viral infections, and vascular remodeling, which is linked to cardiovascular diseases such as coronary artery disease, abdominal aortic aneurysm, heart failure, and diabetic heart disease. The effects of microRNA-155 in different cell types through different target genes result in different mechanisms in diseases. MicroRNA-155 has been intensively studied in atherosclerosis and coronary artery disease. Contradictory results of microRNA-155 either promoting or preventing the pathophysiological process of atherosclerosis illustrate the complexity of this pleiotropic molecule. Therefore, more comprehensive studies of the underlying mechanisms of microRNA-155 involvement in cardiovascular diseases are required. Furthermore, a recent clinical trial of Miravirsen targeting microRNA-122 sheds light on exploiting microRNA-155 as a novel target to develop effective therapeutic strategies for cardiovascular diseases in the near future.
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页数：5
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