Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum

被引：26

作者：

Cheng, Jin-Tang ^{[1
,2
]}

Liu, Fei ^{[1
,2
]}

Li, Xiao-Nian ^{[1
]}

Wu, Xing-De ^{[1
]}

Dong, Liao-Bin ^{[1
,2
]}

Peng, Li-Yan ^{[1
]}

Huang, Sheng-Xiong ^{[1
]}

He, Juan ^{[1
]}

Zhao, Qin-Shi ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 10期

基金：

中国国家自然科学基金;

关键词：

HUPERZINE-A; BIOSYNTHESIS; SKELETON;

D O I：

10.1021/ol400907v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lycospidine A (1), the first example of a Lycopodium alkaloid which contains an unprecedented five-membered A ring, was Isolated from Lycopodium complanatum. The unique five-membered A ring in 1 indicates that carbons 2-5 in 1 are presumably derived from proline Instead of the lysine biosynthetically, which suggests that 1 represent a new class of Lycopodium alkaloid. In addition, the unique structural feature and biosynthetic origin of 1 shed new insight into the structural diversity of Lycopodium alkaloid analogue libraries potentially accessible by engineered biosynthesis.

引用

页码：2438 / 2441

页数：4

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