Three new acylated prenylflavonol glycosides from Epimedium koreanum

Phytochemical investigation on the EtOAc extract of the aerial parts of Epimedium koreanum led to the isolation of three new acylated prenylflavonol glycosides, korepimeosides A-C (1-3), together with twenty known ones (4-23). The structures of three new compounds (1-3) were established on the basis of chemical and spectroscopic methods as icaritin 3-O-[2,6-O-diacetyl-beta-D-glucopyranosyl(1 -> 3)-4-O-acetyl- alpha-L-rhamnopyranoside] (1), icaritin 3-O-[3,6-O-diacetyl-beta-D-glucopyranosyl(1 -> 3)-4-O-acetyla- L-rhamnopyranoside] (2), and icaritin 3-O-[3,-O-acetyl-beta-D-glucopyranosyl(1 -> 3)-4-O-acetyl-alpha-L-rhamnopyranoside], 7-O-beta-D glucopyranoside (3). (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.