MK-10 clay catalyzed, one pot, three component and efficient synthesis of novel 4-(2′,5′-disubstituted-1′H-indol-3′-yl)-2,6-bis(2",5"-disubstituted-1"H-indol-3"-yl) pyridine-3,5-dicarbonitrile under conventional and microwave irradiation

被引:11
|
作者
Biradar, J. S. [1 ]
Sharanbasappa, B. [1 ]
机构
[1] Gulbarga Univ, Dept Chem, Gulbarga, Karnataka, India
关键词
indole; pyridine; microwave irradiation; solid support; conventional method; environmental benign; PYRIDINE; INDOLES;
D O I
10.1080/17518250903393890
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A series of title compounds were synthesized via a one pot, multicomponent reaction of 2,5-disubstituted indole 3-carboxaldehydes, 3-cyanoacetyl indoles, and ammonium acetate under microwave irradiation and conventional method in a short time to afford the corresponding products in high yields. It is an ideal, efficient, and environmental benign reaction. The structures of products thus obtained are confirmed by their melting point, IR, (HNMR)-H-1, and mass spectral data.
引用
收藏
页码:237 / 241
页数:5
相关论文
共 50 条
  • [31] A "One Pot," Environmentally Friendly, Multicomponent Synthesis of 2-Amino-5-cyano-4-[(2-aryl)-1H-indol-3-yl]-6-hydroxypyrimidines and Their Antimicrobial Activity
    Gupta, Ragini
    Jain, Anshu
    Madan, Yogita
    Menghani, Ekta
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 51 (05) : 1395 - 1403
  • [32] Catalytic synthesis and antimicrobial activity of N-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(1H-indol-3-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides
    Desai, Nisheeth C.
    Bhatt, Malay J.
    HETEROCYCLIC COMMUNICATIONS, 2016, 22 (03) : 131 - 136
  • [33] DESIGN, SYNTHESIS, DOCKING STUDY AND PHARMACOLOGICAL EVALUATION OF NOVEL -2- (5-(1H-INDOL-3-YL)- 1, 3, 4-THIADIAZOL -2 -YLIMINO) -5 -(SUBSTITUTED BENZYLIDENE) THIAZOLIDIN-4-ONE ANALOGUES
    Taya, Poonam
    Mehta, Dinesh Kumar
    Das, Rina
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2019, 10 (02): : 701 - 711
  • [34] Crystal structures of three indole derivatives: 3-ethnyl-2-methyl-1-phenylsulfonyl-1H-indole, 4-phenylsulfonyl-3H, 4H-cyclopenta[b] indol-1(2H)-one and 1-{2-[(E)-2-(5-chloro-2-nitrophenyl) ethenyl]-1-phenylsulfonyl-1H-indol-3-yl} ethan-1-one chloroform monosolvate
    Gopinath, S.
    Sethusankar, K.
    Ramalingam, Bose Muthu
    Mohanakrishnan, Arasambattu K.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2015, 71 : 1036 - +
  • [35] Synthesis of novel 2-amino-4-(5′-substituted 2′-phenyl-1H-indol-3′-yl)-6-aryl-4H-pyran-3-carbonitrile derivatives as antimicrobial and antioxidant agents
    Saundane, Anand R.
    Vijaykumar, Katkar
    Vaijinath, A. Verma
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (07) : 1978 - 1984
  • [36] Simple One-Pot Synthesis of Novel 5-(3,5-Dialkyl-1H-pyrazol-1-yl)-2-ethoxy-1,4,2λ5-diazaphosphole 2-Oxides
    Assiri, M. A.
    Ali, T. E.
    Alzahrani, A. Y.
    Salem, M. A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2023, 59 (02) : 285 - 289
  • [37] Simple One-Pot Synthesis of Novel 5-(3,5-Dialkyl-1H-pyrazol-1-yl)-2-ethoxy-1,4,2λ5-diazaphosphole 2-Oxides
    M. A. Assiri
    T. E. Ali
    A. Y. Alzahrani
    M. A. Salem
    Russian Journal of Organic Chemistry, 2023, 59 : 285 - 289
  • [38] Evaluation of diethyl 4-(5-bromo-1H-indol-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate: synthesis, anti-corrosion potential, and biomedical applications
    Ahamed, F. M. Mashood
    Padusha, M. Syed Ali
    Banu, A. Mushira
    Maitra, Swastika
    Alharbi, Hanan M.
    Kumarasamy, Vinoth
    Uti, Daniel E.
    Mohite, Popat
    Alexiou, Athanasios
    Ali, Iftikhar
    BMC CHEMISTRY, 2024, 18 (01)
  • [39] Synthesis and Primary Antitumor Screening of 4-[5-(1H-Indol-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamides
    V. Ya. Horishny
    V. S. Matiychuk
    Russian Journal of Organic Chemistry, 2020, 56 : 1146 - 1152
  • [40] Synthesis and Primary Antitumor Screening of 4-[5-(1H-Indol-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamides
    Horishny, V. Ya.
    Matiychuk, V. S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (07) : 1146 - 1152