Oxidized LDL receptor 1 (OLR1) SNPs and CAD: a case-control association study in a North Indian population

The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/L0X-1) is the major receptor for oxidized LDL on the endothelium. Single nucleotide polymorphisms (SNPs) in OLR1 may play an important role in pathogenesis of atherosclerosis. We investigated G501C, IVS4-73C>T, 3'UTR 188C>T SNPs of OLR1 gene in 329 patients with coronary artery disease (CAD) and 331 age and sex-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. A significant association was observed for C allele (OLR1 G501C) with coronary artery disease (C allele frequency; CAD 0.178, control 0.098,p = 0.00, odds ratio (OR) 1.99, 95% CI 1.42-2.78). However, no association was found for the IVS4-73C>T (T allele frequency; CAD 0.40, control 0.388, p = 0.66, OR 1.05, 95% CI 0.84-1.32) and 3'UTR 188C>T (T allele frequency; CAD 0.33, control 0.307, OR 1.13, 95% CI 0.89-1.43) polymorphisms of OLR1 gene. Coronary artery disease is significantly associated with G501C polymorphism but is not associated with the IVS4-73C>T and 3'UTR 188C>T polymorphisms of OLR1 gene in North India.