JZP815, a potent and selective pan-RAF inhibitor, demonstrates efficacy in RAF and RAS mutant tumor pre-clinical models

被引:0
|
作者
Hauptschein, Robert [1 ]
Woodcock, Simon [2 ]
Belfield, Andrew [2 ]
Mason, Helen [2 ]
Keppel, Dorottya [2 ]
Markova, Svetlana [1 ]
Kim, Kyuri [1 ]
Roller, Shane [1 ]
Phillips, Caroline [2 ]
Jones, Clifford D. [2 ]
Humphreys, Robin C. [1 ]
机构
[1] Jazz Pharmaceut, Palo Alto, CA USA
[2] Redx Pharma, Manchester, Lancs, England
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2677
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Amdizalisib (HMPL-689), a highly selective PI3Kd inhibitor, exhibits potent anti-tumor activity in pre-clinical B-cell lymphoma models
    Hu, Jia
    Wang, Jianhan
    Dai, Xiaoming
    He, Jianlin
    Liang, Junqing
    Yu, Ying
    Yu, Juntao
    Yang, Na
    Wang, Linfang
    Cai, Yu
    Li, Xiong
    Qing, Weiguo
    Ren, Yongxin
    Su, Weiguo
    CANCER RESEARCH, 2022, 82 (12)
  • [42] Design and rationale of a first in human (FIH) phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF- and NRAS-mutation positive solid tumors.
    McKean, Meredith
    Perez, Cesar A.
    Kato, Shumei
    Spira, Alexander I.
    Xing, Yan
    Xie, Hao
    Millward, Michael
    Olszanski, Anthony
    Kobayashi, Ken
    Miller, Nichol
    Severson, Paul
    Tam, Betty
    Unger, Caro
    CANCER RESEARCH, 2022, 82 (12)
  • [43] Efficacy advantages of a novel pan-RAS inhibitor, ADT-1004, over mutant- specific KRAS inhibitors for suppressing pancreatic tumor growth in murine models
    Bandi, Dhana Sekhar Reddy
    Nagaraju, Ganji P.
    Foote, Jeremy B.
    Keeton, Adam B.
    Chen, Xi
    Berry, Kristy L.
    Maxuitenko, Yulia Y.
    Manne, Upender
    Buchsbaum, Donald J.
    Piazza, Gary A.
    El-Rayes, Bassel F.
    CANCER RESEARCH, 2024, 84 (17)
  • [44] ABN401 demonstrates robust anti-tumor efficacy in orthotopic PDX models of MET-driven NSCLC brain metastases in a pre-clinical study
    Rajasekaran, Nirmal
    Park, Kyung Eui
    Lee, Saehyung
    Kim, Na Young
    Chung, Suk-Jae
    Shin, Young Kee
    Choi, Jun Young
    CANCER RESEARCH, 2023, 83 (07)
  • [45] The FHP01 DDX3X Helicase Inhibitor Exerts Potent Anti-Tumor Activity In Vivo in Breast Cancer Pre-Clinical Models
    Gherardini, Lisa
    Inzalaco, Giovanni
    Imperatore, Francesco
    D'Aurizio, Romina
    Franci, Lorenzo
    Miragliotta, Vincenzo
    Boccuto, Adele
    Calandro, Pierpaolo
    Andreini, Matteo
    Tarditi, Alessia
    Chiariello, Mario
    CANCERS, 2021, 13 (19)
  • [46] GDC-0214 Is a Potent Inhaled JAK Inhibitor With Efficacy in Multiple Pre-clinical Models of Th2 Inflammation: A Perspective on Use of In Vivo Rodent Models for Early Phase Drug Discovery
    Eller, C. Rinderknecht
    Rardin, H.
    Sambamurthy, N.
    Thadani, C.
    Wu, X.
    Liu, J.
    Suto, E.
    Gulati, I.
    Zhang, J.
    Kallapur, K.
    Kim, C.
    Tan, S.
    Wang, L.
    Yanez, E.
    Reiss, A.
    Zhang, X.
    Dale, S.
    Cui, Y.
    Lee, W.
    Sethuraman, V.
    Wilson, M.
    Johnson, A.
    Ning, M.
    Grandner, J.
    Briggs, M.
    Rajapaksa, N.
    Durk, M.
    Wright, M.
    Zak, M.
    Kenny, J.
    Ghilardi, N.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
  • [47] Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
    Nishiguchi, Gisele A.
    Rico, Alice
    Tanner, Huw
    Aversa, Robert J.
    Taft, Benjamin R.
    Subramanian, Sharadha
    Setti, Lina
    Burger, Matthew T.
    Wan, Lifeng
    Tamez, Victoriano
    Smith, Aaron
    Lou, Yan
    Barsanti, Paul A.
    Appleton, Brent A.
    Mamo, Mulugeta
    Tandeske, Laura
    Dix, Ina
    Tellew, John E.
    Huang, Shenlin
    Griner, Lesley A. Mathews
    Cooke, Vesselina G.
    Van Abbema, Anne
    Merritt, Hanne
    Ma, Sylvia
    Gampa, Kalyani
    Feng, Fei
    Yuan, Jing
    Wang, Yingyun
    Haling, Jacob R.
    Vaziri, Sepideh
    Hekmat-Nejad, Mohammad
    Jansen, Johanna M.
    Polyakov, Valery
    Zang, Richard
    Sethuraman, Vijay
    Amiri, Payman
    Singh, Mallika
    Lees, Emma
    Shao, Wenlin
    Stuart, Darrin D.
    Dillon, Michael P.
    Ramurthy, Savithri
    JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (12) : 4869 - 4881
  • [48] VS-5584, a dual PI3K/mTOR inhibitor, demonstrates robust activity in pre-clinical models of SCLC with the inhibition of both cancer stem cells and bulk tumor cells
    Kolev, V.
    Wang, Y.
    Sprott, K.
    Padval, M.
    Pachter, J.
    Weaver, D.
    EUROPEAN JOURNAL OF CANCER, 2015, 51 : S53 - S53
  • [49] An Fc-Competent Anti-Human TIGIT Blocking Antibody Ociperlimab (BGB-A1217) Elicits Strong Immune Responses and Potent Anti-Tumor Efficacy in Pre-Clinical Models
    Chen, Xin
    Xue, Liu
    Ding, Xiao
    Zhang, Jing
    Jiang, Lei
    Liu, Sha
    Hou, Hongjia
    Jiang, Bin
    Cheng, Liang
    Zhu, Qing
    Zhang, Lijie
    Zhou, Xiaosui
    Ma, Jie
    Liu, Qi
    Li, Yucheng
    Ren, Zhiying
    Jiang, Beibei
    Song, Xiaomin
    Song, Jing
    Jin, Wei
    Wei, Min
    Shen, Zhirong
    Liu, Xuesong
    Wang, Lai
    Li, Kang
    Zhang, Tong
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [50] A Fc-competent anti-human TIGIT blocking antibody BGB-A1217 elicits strong immune responses and potent anti-tumor efficacy in pre-clinical models.
    Chen, Xin
    Xue, Liu
    Ding, Xiao
    Liu, Qi
    Zhang, Jing
    Jiang, Lei
    Liu, Sha
    Hou, Hongjia
    Zhu, Qing
    Jiang, Bin
    Zhang, Lijie
    Zhou, Xiaosui
    Ma, Jie
    Li, Yucheng
    Jin, Wei
    Wei, Min
    Shen, Zhirong
    Liu, Mike
    Li, Kang
    Zhang, Tong
    CANCER RESEARCH, 2021, 81 (13)