Cyclohexadepsipeptides from the Filamentous Fungus Acremonium sp BCC 2629

被引：11
|
作者：
Bunyapaiboonsri, Taridaporn [1 ]
Vongvilai, Pornrapee [1 ]
Auncharoen, Patchanee [1 ]
Isaka, Masahiko [1 ]
机构：
[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Klong Laung 12120, Pathumthani, Thailand
来源：
HELVETICA CHIMICA ACTA | 2012年 / 95卷 / 06期
关键词：
Cyclohexadepsipeptides; Acremonium species; Beauvericin; Enniatin; Fungi; Peptides; PRECURSOR-DIRECTED BIOSYNTHESIS; VERTICILLIUM-HEMIPTERIGENUM; STRUCTURE ELUCIDATION; BEAUVERICIN ANALOGS; ASSAY;
D O I：
10.1002/hlca.201100482
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Seven new cyclohexadepsipeptides, beauvenniatins F, G1, G2, G3, H1, H2, and H3 (17, resp.), were isolated from cultures of the fungus Acremonium sp. BCC 2629. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations were addressed by HPLC analyses of their acid hydrolysates. Their biological activities were evaluated against Mycobacterium tuberculosis H37Ra and Plasmodium falciparum K1; the respective MIC and IC50 values were in the micromolar range.
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页码：963 / 972
页数：10
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