Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

被引：15

作者：

Washizaki, Ayaka ^{[1
]}

Murayama, Asako ^{[2
]}

Murata, Megumi ^{[1
]}

Kiyohara, Tomoko ^{[2
]}

Yato, Keigo ^{[2
]}

Yamada, Norie ^{[2
]}

Aly, Hussein Hassan ^{[2
]}

Tanaka, Tomohisa ^{[3
]}

Moriishi, Kohji ^{[3
,4
]}

Nishitsuji, Hironori ^{[5
]}

Shimotohno, Kunitada ^{[6
]}

Goh, Yasumasa ^{[7
]}

Ishii, Ken J. ^{[8
]}

Yotsuyanagi, Hiroshi ^{[9
]}

Muramatsu, Masamichi ^{[2
]}

Ishii, Koji ^{[10
]}

Takahashi, Yoshimasa ^{[11
]}

Suzuki, Ryosuke ^{[2
]}

Akari, Hirofumi ^{[1
]}

Kato, Takanobu ^{[2
]}

机构：

[1] Kyoto Univ, Ctr Evolutionary Origins Human Behav, Inuyama, Aichi, Japan

[2] Natl Inst Infect Dis, Dept Virol 2, Tokyo, Japan

[3] Univ Yamanashi, Grad Sch Med, Dept Microbiol, Kofu, Yamanashi, Japan

[4] Hokkaido Univ, Inst Genet Med, Div Hepatitis Virol, Sapporo, Hokkaido, Japan

[5] Fujita Hlth Univ, Sch Med, Dept Virol & Parasitol, Toyoake, Aichi, Japan

[6] Natl Ctr Global Hlth & Med, Genome Med Sci Project, Chiba, Japan

[7] Beacle Inc, Res Lab, Kyoto, Japan

[8] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Vaccine Sci, Tokyo, Japan

[9] Univ Tokyo, Adv Clin Res Ctr, Inst Med Sci, Div Infect Dis, Tokyo, Japan

[10] Natl Inst Infect Dis, Dept Qual Assurance Radiat Safety & Informat Syst, Tokyo, Japan

[11] Natl Inst Infect Dis, Res Ctr Drug & Vaccine Dev, Tokyo, Japan

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

关键词：

SURFACE-ANTIGEN; UNIVERSAL VACCINATION; IMPLEMENTATION; PURIFICATION; PARTICLES; MUTANT; GENE;

D O I：

10.1038/s41467-022-32910-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We investigate an HB vaccine consisting of large-HBsAg that overcomes the shortcomings of the current HB vaccine. Yeast-derived large-HBsAg is immunized into rhesus macaques, and the neutralizing activities of the induced antibodies are compared with those of the current HB vaccine. Although the antibodies induced by the current HB vaccine cannot prevent HBV infection with VEMs, the large-HBsAg vaccine-induced antibodies neutralize those infections. The HBV genotypes that exhibited attenuated neutralization via these vaccines are different. Here, we show that the HB vaccine consisting of large-HBsAg is useful to compensate for the shortcomings of the current HB vaccine. The combined use of these HB vaccines may induce antibodies that can neutralize HBV strains with VEMs or multiple HBV genotypes.

引用

页数：12

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