GC/GC-MS Analysis, Isolation and Identification of Bioactive Essential Oil Components from the Bhutanese Medicinal Plant, Pleurospermum amabile

被引：0

作者：

Wangchuk, Phurpa ^{[1
,2
]}

Keller, Paul A. ^{[1
]}

Pyne, Stephen G. ^{[1
]}

Taweechotipatr, Malai ^{[3
]}

Kamchonwongpaisan, Sumalee ^{[4
]}

机构：

[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia

[2] Minist Hlth, Manjong Sorig Pharmaceut, Thimphu, Bhutan

[3] Srinakharinwirot Univ, Fac Med, Dept Microbiol, Bangkok 10110, Thailand

[4] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Med Mol Biol Res Unit, Pathum Thani 12120, Thailand

来源：

NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 09期

关键词：

Pleurospermum amabile; Medicinal plant; Essential oil; (E)-isomyristicin; Antibacterial; Antimalarial; Multidrug resistant strain; Cytotoxicity; ANTIMALARIAL;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have hydrodistilled the essential oil (EO) from the aerial parts of the Bhutanese medicinal plant, Pleurospermum amabile using a Clevenger apparatus and evaluated this EO by GC/GC-MS and NMR analysis followed by testing for bioactivity. The GC-MS analysis identified 52 compounds with (E)-isomyristicin as a major component (32.2%). Repeated purification yielded four compounds; (E)-isomyristicin (1), (E)-isoapiol (2), methyl eugenol (3) and (E)-isoelemicin (4). Compound 2 and the mother EO showed the best antiplasmodial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). They exhibited mild antibacterial activity against Bacillus subtilis. None of the test samples showed cytotoxicity.

引用

页码：1305 / 1308

页数：4

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