A novel composite scaffold consisted of porous titanium and chitosan sponge for load-bearing applications: Fabrication, characterization and cellular activity

被引：26
|
作者：
Li, Xiang [1 ]
Ma, Xiang-Yu [2 ]
Feng, Ya-Fei [2 ]
Wang, Lin [2 ]
Wang, Chengtao [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Mech Engn, State Key Lab Mech Syst & Vibrat, Shanghai 200240, Peoples R China
[2] Fourth Mil Med Univ, Dept Orthoped, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China
来源：
COMPOSITES SCIENCE AND TECHNOLOGY | 2015年 / 117卷
基金：
中国国家自然科学基金;
关键词：
Hybrid composites; Mechanical properties; Biocompatibility; IN-VITRO; BONE; IMPLANTS; PARTS;
D O I：
10.1016/j.compscitech.2015.05.019
中图分类号：
TB33 [复合材料];
学科分类号：
摘要：
A novel composite scaffold consisting of porous Ti part filled with chitosan/HA sponge was fabricated using a combination of electron beam melting and freeze-drying. The mechanical properties of porous Ti with porosities of similar to 60-75% were examined via compressive test. The compression strength values of the samples were ranged from 86.35 (+/- 12.68) - 180.21 (+/- 10.26) MPa and stiffness values were of 2.23 (+/- 0.68) - 5.48 (+/- 0.54) GPa. The microstructure of composite scaffold was characterized using scanning electron microscopy. The chitosan/HA sponge filled in Ti part exhibited highly porous and well-interconnected pore architecture, which is produced to accommodate cells without the need to meet mechanical requirements. The in vitro biocompatibility of the composite scaffolds was investigated using rat osteoblasts. Compared with pure Ti part, composite scaffolds exhibited higher biological activity, such as an improved osteoblast adhesion and morphology, increased proliferation and alkaline phosphatase (ALP) activity. These results suggest that the composite scaffold is potentially useful as a biomedical scaffold for bone repair in load-bearing sites. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：78 / 84
页数：7
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