Acute leukoencephalopathy due to pyrimethamine. An insight into methotrexate neurotoxicity?

被引：2
|
作者：
de Broucker, Thomas [1 ]
Leclercq, Delphine [2 ]
Jarquin, Sergio [2 ]
Henry, Carole [1 ]
机构：
[1] Hop Delafontaine, Serv Neurol, F-93200 St Denis, France
[2] Grp Hosp Pitie Salpetriere, Serv Neuroradiol, F-75013 Paris, France
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2013年 / 335卷 / 1-2期
关键词：
Leukoencephalopathy; Drug toxicity; Pyrimethamine; Methotrexate; Folinic acid; Myelin synthesis; CHILDREN;
D O I：
10.1016/j.jns.2013.09.032
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A unique case of pyrimethamine-related stroke-like leukoencephalopathy is described. The imputability of the drug is discussed as well as the similarities with the well-known methotrexate neurotoxicity. Owing to the same mode of action of both drugs by inhibition of the enzyme dihydrofolate reductase, this case is highly suggestive of the pathogenetic role of methylation pathway blockade on myelin synthesis resulting in delayed demyelination. This complication could be avoided by a concurrent folinic acid supplementation. (c) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：201 / 203
页数：3
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