Synthesis, Conformational Analysis and Biological Studies of Cyclic Cationic Antimicrobial Peptides Containing Sugar Amino Acids

被引：31

作者：

Chakraborty, Tushar Kanti ^{[1
]}

Koley, Dipankar ^{[1
]}

Ravi, Rapolu ^{[1
]}

Krishnakumari, Viswanatha ^{[2
]}

Nagaraj, Ramakrishnan ^{[2
]}

Kunwar, Ajit Chand ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500607, Andhra Pradesh, India

[2] Ctr Cellular & Mol Biol, Hyderabad 500607, Andhra Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 22期

关键词：

D O I：

10.1021/jo801123q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sugar amino acid based 24-membered macrocycliC C-2-symmetric cationic peptides were designed and synthesized. The cationic group was introduced in the sugar amino acids. The conformation of these cyclic compounds was ascertained through NMR techniques, which proved they were amphipathic in nature. All the compounds were bacteriolytic, showed good activity against the Gr(+v)e and Gr(-ve) bacteria, and exhibited low hemolytic activity.

引用

页码：8731 / 8744

页数：14

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