The pathophysiology of the intervertebral disc

被引：117
|
作者：
Bibby, SRS [1 ]
Jones, DA [1 ]
Lee, RB [1 ]
Yu, J [1 ]
Urban, JPG [1 ]
机构：
[1] Univ Oxford, Phys Lab, Oxford OX1 3PT, England
来源：
JOINT BONE SPINE | 2001年 / 68卷 / 06期
关键词：
collagen; disk cells; disk degeneration; low back pain; proteoglycan; scoliosis;
D O I：
10.1016/S1297-319X(01)00332-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
After a review of disk structure, the pivotal role of disk cells in producing and renewing the extracellular disk matrix is emphasized. Disk cells rely on nutrients that diffuse through the vertebral endplates. Microelectrode methods have been developed to study nutrient diffusion and endplate permeability. Mechanical stimuli modify disk cell activity. Scoliosis is associated with decreased endplate permeability, a factor that may play a role in disk degeneration and scoliosis progression. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：537 / 542
页数：6
相关论文
共 50 条
  • [21] THE INTERVERTEBRAL DISC
    Montagu, M. F. Ashley
    [J]. PSYCHIATRY, 1941, 4 (04) : 635 - 636
  • [22] Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration
    Bergknut, Niklas
    Smolders, Lucas A.
    Grinwis, Guy C. M.
    Hagman, Ragnvi
    Lagerstedt, Anne-Sofie
    Hazewinkel, Herman A. W.
    Tryfonidou, Marianna A.
    Meij, Bjorn P.
    [J]. VETERINARY JOURNAL, 2013, 195 (03): : 282 - 291
  • [23] The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
    Sun, Zhen
    Liu, Bing
    Luo, Zhuo-Jing
    [J]. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2020, 17 (05): : 685 - 692
  • [24] Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications
    Lappalainen, Anu K.
    Vaittinen, Elina
    Junnila, Jouni
    Laitinen-Vapaavuori, Outi
    [J]. ACTA VETERINARIA SCANDINAVICA, 2014, 56 : 89
  • [25] Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications
    Anu K Lappalainen
    Elina Vaittinen
    Jouni Junnila
    Outi Laitinen-Vapaavuori
    [J]. Acta Veterinaria Scandinavica, 56
  • [26] Degeneration of the intervertebral disc
    Urban, JPG
    Roberts, S
    [J]. ARTHRITIS RESEARCH & THERAPY, 2003, 5 (03) : 120 - 130
  • [27] Piezoelectricity in the Intervertebral disc
    Poillot, Philip
    O'Donnell, Joseph
    O'Connor, David T.
    Ul Haq, Ehtsham
    Silien, Christophe
    Tofail, Syed A. M.
    Huyghe, Jacques M.
    [J]. JOURNAL OF BIOMECHANICS, 2020, 102
  • [28] Degeneration of the intervertebral disc
    Jill PG Urban
    Sally Roberts
    [J]. Arthritis Res Ther, 5
  • [29] Sciatica and the intervertebral disc
    Fraser, I
    [J]. LANCET, 1940, 1 : 945 - 946
  • [30] Sciatica and the intervertebral disc
    Pennnybacker, J
    [J]. LANCET, 1940, 1 : 771 - 777
12345