Microwave-assisted synthesis of 3'-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

被引：63
|
作者：
Kathrotiya, Harshad G. [1 ]
Patel, Manish P. [1 ]
机构：
[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期
关键词：
4H-Chromene; Indole; DMAP; Microwave irradiation; MCR; In vitro antimicrobial activity; ONE-POT SYNTHESIS; IN-VITRO; ANTIBACTERIAL ACTIVITY; CHROMENE DERIVATIVES; BIOLOGICAL-ACTIVITY; ANTIOXIDANT; BENZIMIDAZOLES; IRRADIATION; INDOLES; BEARING;
D O I：
10.1007/s00044-011-9861-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new series of indole-based chromene derivatives 4a-4p has been synthesized by one pot cyclocondensation reaction of 2-phenyl-1H-indole-3-carbaldehyde 1a-1h; malononitrile 2; and 1,3-cyclohexanedione/dimedone 3a/b under microwave irradiation catalyzed by an organocatalyst 4-(N,N-dimethylamino) pyridine. Easy experimental procedure, high yield, selectivity, and shorter reaction time are the imperative features of this method. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than that of standard drugs as evident from SAR study.
引用
收藏
页码：3406 / 3416
页数：11
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