Microwave-assisted synthesis of 3'-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

被引：62

作者：

Kathrotiya, Harshad G. ^{[1
]}

Patel, Manish P. ^{[1
]}

机构：

[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期

关键词：

4H-Chromene; Indole; DMAP; Microwave irradiation; MCR; In vitro antimicrobial activity; ONE-POT SYNTHESIS; IN-VITRO; ANTIBACTERIAL ACTIVITY; CHROMENE DERIVATIVES; BIOLOGICAL-ACTIVITY; ANTIOXIDANT; BENZIMIDAZOLES; IRRADIATION; INDOLES; BEARING;

D O I：

10.1007/s00044-011-9861-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of indole-based chromene derivatives 4a-4p has been synthesized by one pot cyclocondensation reaction of 2-phenyl-1H-indole-3-carbaldehyde 1a-1h; malononitrile 2; and 1,3-cyclohexanedione/dimedone 3a/b under microwave irradiation catalyzed by an organocatalyst 4-(N,N-dimethylamino) pyridine. Easy experimental procedure, high yield, selectivity, and shorter reaction time are the imperative features of this method. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than that of standard drugs as evident from SAR study.

引用

页码：3406 / 3416

页数：11

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