An improved synthesis of 5-(2,6-dichlorophenyl)-2-(phenyl-thio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

被引：8
|
作者：
Treu, M
Jordis, U
Lee, VJ
机构：
[1] Vienna Tech Univ, Inst Organ Chem, A-1060 Vienna, Austria
[2] Iconix Pharmaceut Inc, Mt View, CA 94043 USA
来源：
MOLECULES | 2001年 / 6卷 / 12期
关键词：
nucleophilic substitution; DMF-acetal heterocyclization;
D O I：
10.3390/M274
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An improved procedure for the synthesis an analog of the p38 inhibitor compound VX-745 is reported.
引用
收藏
页码：959 / 963
页数：5
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