Copper-Catalyzed Aerobic Spirocyclization of Biaryl-N-H-imines via 1,4-Aminooxygenation of Benzene Rings

被引：48
|
作者：
Tnay, Ya Lin [1 ]
Chen, Cheng [1 ]
Chua, Yi Yuan [1 ]
Zhang, Line [1 ]
Chiba, Shunsuke [1 ]
机构：
[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 13期
关键词：
OXIDATIVE AMIDATION; AXIAL CHIRALITY; BOND FORMATION; FUNCTIONALIZATIONS; DEAROMATIZATION; DERIVATIVES; ALKYNES; ACCESS; OXYGEN; SCOPE;
D O I：
10.1021/ol301583y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.
引用
收藏
页码：3550 / 3553
页数：4
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