Synergic asymmetric organocatalysis (SAOc) of Cinchona alkaloids and secondary amines in the synthesis of bicyclo[2.2.2]octan-2-ones

被引：42
|
作者：
Bella, Marco [1 ]
Schietroma, Daniele M. Scarpino
Cusella, Pier Paolo
Gasperi, Tecla
Visca, Valerio
机构：
[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy
来源：
CHEMICAL COMMUNICATIONS | 2009年 / 05期
关键词：
MICHAEL ADDITION; ALPHA; BETA-UNSATURATED ALDEHYDES; CONJUGATE ADDITION; CATALYSIS; CASCADE; KETONES; STEREOCENTERS; CONSTRUCTION; ANNULATION; MALONATE;
D O I：
10.1039/b816550e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A synergistic effect between chiral secondary and tertiary amines gives access to bicyclo[2.2.2]octan-2-ones with up to 90% ee and > 10 : 1 dr.
引用
收藏
页码：597 / 599
页数：3
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