Synergic asymmetric organocatalysis (SAOc) of Cinchona alkaloids and secondary amines in the synthesis of bicyclo[2.2.2]octan-2-ones

被引：42

作者：

Bella, Marco ^{[1
]}

Schietroma, Daniele M. Scarpino

Cusella, Pier Paolo

Gasperi, Tecla

Visca, Valerio

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 05期

关键词：

MICHAEL ADDITION; ALPHA; BETA-UNSATURATED ALDEHYDES; CONJUGATE ADDITION; CATALYSIS; CASCADE; KETONES; STEREOCENTERS; CONSTRUCTION; ANNULATION; MALONATE;

D O I：

10.1039/b816550e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synergistic effect between chiral secondary and tertiary amines gives access to bicyclo[2.2.2]octan-2-ones with up to 90% ee and > 10 : 1 dr.

引用

页码：597 / 599

页数：3

共 22 条

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Kokotos, Christoforos G.
CHEMICAL COMMUNICATIONS, 2013, 49 (22) : 2219 - 2221
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TETRAHEDRON, 1998, 54 (46) : 14015 - 14022
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