Chiral-at-Metal Octahedral Iridium Catalyst for the Asymmetric Construction of an All-Carbon Quaternary Stereocenter

被引：106
|
作者：
Chen, Liang-An [1 ,2 ]
Tang, Xiaojuan [1 ,2 ]
Xi, Jianwei [1 ,2 ]
Xu, Weici [1 ,2 ]
Gong, Lei [1 ,2 ]
Meggers, Eric [1 ,2 ,3 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Biol Chem, Xiamen 361005, Peoples R China
[3] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 52期
关键词：
asymmetric catalysis; chirality; hydrogen bonds; iridium; quaternary stereocenter; FRIEDEL-CRAFTS ALKYLATION; ENANTIOSELECTIVE CONSTRUCTION; STEREOGENIC CENTERS; CONJUGATE ADDITION; BOND DONORS; COMPLEXES; ORGANOCATALYSIS; HYDROGENATION; NITROALKENES; POTASSIUM;
D O I：
10.1002/anie.201306997
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Metal-templated organocatalysis: The enantioselective formation of an all-carbon quaternary stereocenter is catalyzed by the ligand sphere of an inert bis-cyclometalated iridium complex (see picture). In this complex, the metal-centered chirality serves as the sole source for the effective asymmetric induction. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：14021 / 14025
页数：5
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